GLYCOPATHOLOGY OF FETOPLACENTAL-MATERNAL SYSTEM IN THE «GREAT OBSTETRICAL SYNDROMES» ASSOCIATED WITH DISORDERS OF DEEP PLACENTATION
- Authors: Ziganshina M.M.1, Shilova N.V.1,2,3, Kulikova G.V.1, Khasbiullina N.R.1,4,3, Shchegolev A.I.1, Nokel A.Y.1,3, Dolgopolova E.L.1, Bovin N.V.2
-
Affiliations:
- National Medical Research Center for Obstetrics, Gynecology and Perinatology named after Academician V. I. Kulakov of the Ministry of Healthcare of Russian Federation
- Federal Budget Institution of Science «M. M. Shemyakin and Yu. A. Ovchinnikov Institute of Bioorganic Chemistry»
- Semiotik LLC
- Federal Budget Institution of Science « N. D. Zelinsky Institute of Organic Chemistry»
- Issue: Vol 22, No 2-1 (2019)
- Pages: 267-269
- Section: ORIGINAL ARTICLES
- URL: https://journals.rcsi.science/1028-7221/article/view/119733
- DOI: https://doi.org/10.31857/S102872210006596-0
- ID: 119733
Cite item
Full Text
Abstract
The features of the glycophenotype of the placenta, the repertoire and the content of anti-glycan antibodies of the blood were studied using lectin histochemistry and glycochip in preeclampsia (PE) and fetal growth restriction (FGR), which indicate the development of glycopathology in the fetoplacentalmathernal system and the different pathogenesis of early and late PE and FGR.
About the authors
M. M. Ziganshina
National Medical Research Center for Obstetrics, Gynecology and Perinatology named after Academician V. I. Kulakov of the Ministry of Healthcare of Russian Federation
Author for correspondence.
Email: mmz@mail.ru
PhD, senior scientist of laboratory of clinical immunology,
Moscow
Russian FederationN. V. Shilova
National Medical Research Center for Obstetrics, Gynecology and Perinatology named after Academician V. I. Kulakov of the Ministry of Healthcare of Russian Federation;Federal Budget Institution of Science «M. M. Shemyakin and Yu. A. Ovchinnikov Institute of Bioorganic Chemistry»;
Semiotik LLC
senior scientist of laboratory of clinical immunology;
senior scientist of Department of chemical biology of glycans and lipids;
chief microchip specialist,
Moscow
Russian FederationG. V. Kulikova
National Medical Research Center for Obstetrics, Gynecology and Perinatology named after Academician V. I. Kulakov of the Ministry of Healthcare of Russian Federation
PhD, senior scientist of department of anatomic pathology,
Moscow
Russian FederationN. R. Khasbiullina
National Medical Research Center for Obstetrics, Gynecology and Perinatology named after Academician V. I. Kulakov of the Ministry of Healthcare of Russian Federation;Federal Budget Institution of Science « N. D. Zelinsky Institute of Organic Chemistry»;
Semiotik LLC
staff scientist of laboratory of clinical immunology';
junior scientist of laboratory of carbohydrate chemistry Zelinsky Institute of Organic Chemistry;
microchip specialist,
Moscow
Russian FederationA. I. Shchegolev
National Medical Research Center for Obstetrics, Gynecology and Perinatology named after Academician V. I. Kulakov of the Ministry of Healthcare of Russian Federation
MD, prof., head of the departmenth of anatomic pathology,
Moscow
Russian FederationA. Yu. Nokel
National Medical Research Center for Obstetrics, Gynecology and Perinatology named after Academician V. I. Kulakov of the Ministry of Healthcare of Russian Federation;Semiotik LLC
PhD, senior scientist of laboratory of clinical immunology;
chief engineer,
Moscow
Russian FederationE. L. Dolgopolova
National Medical Research Center for Obstetrics, Gynecology and Perinatology named after Academician V. I. Kulakov of the Ministry of Healthcare of Russian Federation
2nd year resident,
Moscow
Russian FederationN. V. Bovin
Federal Budget Institution of Science «M. M. Shemyakin and Yu. A. Ovchinnikov Institute of Bioorganic Chemistry»
Dr. habil., professor, chief of Department of chemical biology of glycans and lipids,
Moscow
Russian FederationReferences
- Blixt O., Head S., Mondala T., Scanlan C., Hufl ejt M. E., Alvarez R., Bryan M. C., Fazio F., Calarese D., Stevens J., Razi N., Stevens D. J., Skehel J.J., van Die I., Burton D.R., Wilson I.A., Cummings R., Bovin N., Wong C.H., Paulson J.C. Printed covalent glycan array for ligand profi ling of diverse glycan binding proteins. Proc Natl Acad Sci. 2004, 7;101(49):17033–8.
- Huflejt M.E., Vuskovic M., Vasiliu D., Xu H., Obukhova P., Shilova N., Tuzikov A., Galanina O., Arun B., Lu K., Bovin N. Anti-carbohydrate antibodies of normal sera: findings, surprises and challenges. Mol. Immunol. 2009, 46(15): 3037–49.
Supplementary files
