GLYCOPATHOLOGY OF FETOPLACENTAL-MATERNAL SYSTEM IN THE «GREAT OBSTETRICAL SYNDROMES» ASSOCIATED WITH DISORDERS OF DEEP PLACENTATION

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The features of the glycophenotype of the placenta, the repertoire and the content of anti-glycan antibodies of the blood were studied using lectin histochemistry and glycochip in preeclampsia (PE) and fetal growth restriction (FGR), which indicate the development of glycopathology in the fetoplacentalmathernal system and the different pathogenesis of early and late PE and FGR.

作者简介

M. Ziganshina

National Medical Research Center for Obstetrics, Gynecology and Perinatology named after Academician V. I. Kulakov of the Ministry of Healthcare of Russian Federation

编辑信件的主要联系方式.
Email: mmz@mail.ru

PhD, senior scientist of laboratory of clinical immunology,

Moscow

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N. Shilova

National Medical Research Center for Obstetrics, Gynecology and Perinatology named after Academician V. I. Kulakov of the Ministry of Healthcare of Russian Federation;
Federal Budget Institution of Science «M. M. Shemyakin and Yu. A. Ovchinnikov Institute of Bioorganic Chemistry»;
Semiotik LLC

Email: fake@neicon.ru

senior scientist of laboratory of clinical immunology;

senior scientist of Department of chemical biology of glycans and lipids;

chief microchip specialist,

Moscow

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G. Kulikova

National Medical Research Center for Obstetrics, Gynecology and Perinatology named after Academician V. I. Kulakov of the Ministry of Healthcare of Russian Federation

Email: fake@neicon.ru

PhD, senior scientist of department of anatomic pathology,

Moscow

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N. Khasbiullina

National Medical Research Center for Obstetrics, Gynecology and Perinatology named after Academician V. I. Kulakov of the Ministry of Healthcare of Russian Federation;
Federal Budget Institution of Science « N. D. Zelinsky Institute of Organic Chemistry»;
Semiotik LLC

Email: fake@neicon.ru

staff scientist of laboratory of clinical immunology';

junior scientist of laboratory of carbohydrate chemistry Zelinsky Institute of Organic Chemistry;

microchip specialist,

Moscow

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A. Shchegolev

National Medical Research Center for Obstetrics, Gynecology and Perinatology named after Academician V. I. Kulakov of the Ministry of Healthcare of Russian Federation

Email: fake@neicon.ru

MD, prof., head of the departmenth of anatomic pathology,

Moscow

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A. Nokel

National Medical Research Center for Obstetrics, Gynecology and Perinatology named after Academician V. I. Kulakov of the Ministry of Healthcare of Russian Federation;
Semiotik LLC

Email: fake@neicon.ru

PhD, senior scientist of laboratory of clinical immunology;

chief engineer,

Moscow

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E. Dolgopolova

National Medical Research Center for Obstetrics, Gynecology and Perinatology named after Academician V. I. Kulakov of the Ministry of Healthcare of Russian Federation

Email: fake@neicon.ru

2nd year resident,

Moscow

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N. Bovin

Federal Budget Institution of Science «M. M. Shemyakin and Yu. A. Ovchinnikov Institute of Bioorganic Chemistry»

Email: fake@neicon.ru

Dr. habil., professor, chief of Department of chemical biology of glycans and lipids,

Moscow

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参考

  1. Blixt O., Head S., Mondala T., Scanlan C., Hufl ejt M. E., Alvarez R., Bryan M. C., Fazio F., Calarese D., Stevens J., Razi N., Stevens D. J., Skehel J.J., van Die I., Burton D.R., Wilson I.A., Cummings R., Bovin N., Wong C.H., Paulson J.C. Printed covalent glycan array for ligand profi ling of diverse glycan binding proteins. Proc Natl Acad Sci. 2004, 7;101(49):17033–8.
  2. Huflejt M.E., Vuskovic M., Vasiliu D., Xu H., Obukhova P., Shilova N., Tuzikov A., Galanina O., Arun B., Lu K., Bovin N. Anti-carbohydrate antibodies of normal sera: findings, surprises and challenges. Mol. Immunol. 2009, 46(15): 3037–49.

版权所有 © Ziganshina M.M., Shilova N.V., Kulikova G.V., Khasbiullina N.R., Shchegolev A.I., Nokel A.Y., Dolgopolova E.L., Bovin N.V., 2019

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