THE IMPORTANCE OF GENOTYPIC AND IMMUNOPHENOTYPIC CHARACTERISTICS IN THE PATHOGENESIS AND TREATMENT OF CHRONIC HCV-INFECTION
- Authors: Nabieva U.P.1, Ismailova A.A.1, Adylov D.G.1
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Affiliations:
- Republican Scientific Center of Immunology of the Ministry of Health of the Republic of Uzbekistan
- Issue: Vol 20, No 3 (2017)
- Pages: 435-439
- Section: Articles
- URL: https://journals.rcsi.science/1028-7221/article/view/119651
- ID: 119651
Cite item
Abstract
The article is devoted to the investigation of the correspondence of the genotype of the IL-28B gene to the virological, biochemical and immunological parameters of patients with chronic viral hepatitis C in the course of antiviral therapy of pegylated interferon α and ribavirin. It was found that with the genotype of the CC gene of the IL-28B gene at the locus rsl2979860, in which the non-genotype of the hepatitis C virus was most often detected, self-healing and high efficacy of PVT are most often observed. On the part of the organism’s reactogenicity, this was accompanied by a more pronounced cytolytic syndrome and a high immunological reactivity of the organism, manifested in an increase in the expression of cytotoxic lymphocytes CD8+, activation markers CD23+ and CD38+.
About the authors
U. P. Nabieva
Republican Scientific Center of Immunology of the Ministry of Health of the Republic of Uzbekistan
Author for correspondence.
Russian Federation
A. A. Ismailova
Republican Scientific Center of Immunology of the Ministry of Health of the Republic of UzbekistanRussian Federation
D. G. Adylov
Republican Scientific Center of Immunology of the Ministry of Health of the Republic of UzbekistanRussian Federation
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