INFLUENCE OF GLUTAMIL-TRIPTOFAN ON THE EXPRESSION OF IL-8 AND ICAM-1 MONONUCLEAR LEUKOCYTES OF PERIPHERAL BLOOD OF THE PERSON AND CAGES OF THE EA.HY 926 LINE

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Abstract

The aim of the study was to investigate the cell mechanisms mediating immunomodulatory effects of a-glutamyl-tryptophan (EW) and estimate the possibility of this pharmaceutical agent to impact the level of NF-kp phosphorylation. Using in vitro model of inflammation, we tested whether EW impacts spontaneous and TNFa induced IL-8 secretion as well as ICAM-1 expression by endothelial EA.hy 926 cells and mononuclear leukocytes of human peripheral blood. Revealed inhibition of pro-inflammatory cytokine production can contribute to anti-inflammatory effects of EW. However a capability of EW to increase ICAM-1 expression suggests its cell activating function. Thus, due to diverse effects it seems unlikely that EW influences NF-kp directly.

About the authors

T. A. Kudryavtseva

ZAO "MBNPK "Cytomed"

Author for correspondence.
Russian Federation

E. A. Starikova

Institute of Experimental Medicine

Russian Federation

N. A. Aktureeva

Institute of Experimental Medicine

Russian Federation

S. V. Petlenko

ZAO "MBNPK "Cytomed"

Russian Federation

V. S. Smirnov

ZAO "MBNPK "Cytomed"

Russian Federation

N. I. Stukan

ZAO "MBNPK "Cytomed"

Russian Federation

A. V. Lyovina

ZAO "MBNPK "Cytomed"

Russian Federation

References

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Copyright (c) 2017 Kudryavtseva T.A., Starikova E.A., Aktureeva N.A., Petlenko S.V., Smirnov V.S., Stukan N.I., Lyovina A.V.

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