INFLUENCE OF GLUTAMIL-TRIPTOFAN ON THE EXPRESSION OF IL-8 AND ICAM-1 MONONUCLEAR LEUKOCYTES OF PERIPHERAL BLOOD OF THE PERSON AND CAGES OF THE EA.HY 926 LINE

T. A. Kudryavtseva; Кудрявцева Т. А.; E. A. Starikova; Старикова Э. А.; N. A. Aktureeva; Актуреева Н. А.; S. V. Petlenko; Петленко С. В.; V. S. Smirnov; Смирнов В. С.; N. I. Stukan; Стукань Н. И.; A. V. Lyovina; Лёвина А. В.

INFLUENCE OF GLUTAMIL-TRIPTOFAN ON THE EXPRESSION OF IL-8 AND ICAM-1 MONONUCLEAR LEUKOCYTES OF PERIPHERAL BLOOD OF THE PERSON AND CAGES OF THE EA.HY 926 LINE

作者: Kudryavtseva T.¹, Starikova E.², Aktureeva N.², Petlenko S.¹, Smirnov V.¹, Stukan N.¹, Lyovina A.¹
隶属关系:
1. ZAO "MBNPK "Cytomed"
2. Institute of Experimental Medicine
期: 卷 20, 编号 2 (2017)
页面: 157-158
栏目: Articles
URL: https://journals.rcsi.science/1028-7221/article/view/119595
ID: 119595

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The aim of the study was to investigate the cell mechanisms mediating immunomodulatory effects of a-glutamyl-tryptophan (EW) and estimate the possibility of this pharmaceutical agent to impact the level of NF-kp phosphorylation. Using in vitro model of inflammation, we tested whether EW impacts spontaneous and TNFa induced IL-8 secretion as well as ICAM-1 expression by endothelial EA.hy 926 cells and mononuclear leukocytes of human peripheral blood. Revealed inhibition of pro-inflammatory cytokine production can contribute to anti-inflammatory effects of EW. However a capability of EW to increase ICAM-1 expression suggests its cell activating function. Thus, due to diverse effects it seems unlikely that EW influences NF-kp directly.

关键词

глутамил-триптофан, эндотелиальные клетки EA.hy 926, мононуклеар-ные лейкоциты периферической крови человека, ICAM-1, секреция цитокинов, glutamil-tryptophane, endotelialny cages of EA.hy 926, mononuclear leukocytes of peripheral blood of the person, ICAM-1, secretion of cytokin

参考

Смирнов В. С. Современные средства профилактики и лечения гриппа и ОРВИ. СПб: ФАР-МИндекс. - 2010. - ISBN 978-5-91753-015-4.
Smirnov V. S. Modern drugs of prevention and treatment of influenza and acute respiratory viral infections. SPb: PHARMIndex.- 2010.- ISBN 978-5-91753-015-4.
Rahman A., Fazal F. Antioxid Redox Signal.- 2009.-V.11.- № 4.- Р.823-39.
Springer T. A., Dustin M. L. Curr Opin Cell Biol.-2012.- V.24.- № 1.- Р.107-15.

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INFLUENCE OF GLUTAMIL-TRIPTOFAN ON THE EXPRESSION OF IL-8 AND ICAM-1 MONONUCLEAR LEUKOCYTES OF PERIPHERAL BLOOD OF THE PERSON AND CAGES OF THE EA.HY 926 LINE

全文:

详细

关键词

作者简介

T. Kudryavtseva

E. Starikova

N. Aktureeva

S. Petlenko

V. Smirnov

N. Stukan

A. Lyovina

参考