THE INFLAMMATORY PATTERNS IN PATIRNTS WITH BRONCHIAL ASTHMA AND CONCOMITENT OBESITY

Currently, it exists a firm tendency of increased prevalence of the excess body mass and obesity all over the world. In serum samples of 108 children and 51 adults with allergic diseases and bronchial asthma of different degree of severity, we measured the levels of ORP, total IgE, leptin, cytokines and IgE Abs against a number of self-tissue proteins by ELISA method. It was revealed the association between body mass index (BMI) and the clinical manifestations of allergy among children, that were characterizes by 2 times higher frequency of excess BMI in asthma group as compared to children with allergic rhinitis (AR) and atopic dermatitis (AD), without BA. It appeared that the elevation of BMI was also associated with worsening of asthma severity degree and the expanding the range of concomitant diseases. Besides of the enhanced levels of total IgE it was estimated the higher frequency of sIgE-response to environmental Ags. In both groups of adults and children, the obesity was associated with increasing of CRP, leptin and TNF-α in serum, being most enhanced in asthma group. The revealed associations confirm the link between obesity, as a chronic inflammatory condition with atopy and development of asthma.

бронхиальная астма, ожирение, цитокины, asthma, obesity, cytokines