THE ROLE OF PREGNANCY-SPECITIC GLYCOPROTEIN IN THE REGULATION OF PRODUCTION OF KEY CYTOKINES THAT DETERMINE BALANCE Th1 / Th2

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Abstract

The effect of pregnancy-specific glycoprotein (PSG) on the production of Th1/Th2-cytokines by intact mononuclear cells and monocultures of CD4 cells under in vitro conditions by flow-through fluorimetry was studied. It has been established that PSG predominantly suppresses the production of Th1-cytokines (IFN-γ, TNF-α, IL-2) by the types of cells studied, and it regulates the production of Th2-cytokines in different directions, decreasing the production of IL-9, IL-13, IL-6, but increasing the level of IL-5. As a result, PSG forms the integral Th2-cytokine profile of intact peripheral cells of the immune system.

About the authors

S. A. Zamorina

Institute of Ecology and Genetics of Microorganisms UB RAS; Perm State National Research University

Author for correspondence.
Email: noemail@neicon.ru
Russian Federation

L. S. Litvinova

Immanuel Kant Baltic Federal University

Email: noemail@neicon.ru
Russian Federation

K. A. Yurova

Immanuel Kant Baltic Federal University

Email: noemail@neicon.ru
Russian Federation

O. G. Khaziakhmatova

Immanuel Kant Baltic Federal University

Email: noemail@neicon.ru
Russian Federation

V. P. Timganova

Institute of Ecology and Genetics of Microorganisms UB RAS

Email: noemail@neicon.ru
Russian Federation

M. S. Bochkova

Institute of Ecology and Genetics of Microorganisms UB RAS

Email: noemail@neicon.ru
Russian Federation

P. V. Khramtsov

Perm State National Research University

Email: noemail@neicon.ru
Russian Federation

M. B. Rayev

Institute of Ecology and Genetics of Microorganisms UB RAS; Perm State National Research University

Email: noemail@neicon.ru
Russian Federation

References

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  3. Раев М. Б. Cпособ выделения и очистки трофобластического β-1-гликопротеина. Патент РФ № 2367449 от 20.09.2009. / Раев М. Б.// «Изобретения. Полезные модели». 2009. № 26.

Copyright (c) 2017 Zamorina S.A., Litvinova L.S., Yurova K.A., Khaziakhmatova O.G., Timganova V.P., Bochkova M.S., Khramtsov P.V., Rayev M.B.

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This work is licensed under a Creative Commons Attribution 4.0 International License.

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