Study of Surface Morphology of Microfluidic Chip Channels via X-Ray Tomography and Scanning Electron Microscopy

S. V. Chapek; Чапек С. В.; I. A. Pankin; Панкин И. А.; D. V. Khodakova; Ходакова Д. В.; A. A. Guda; Гуда А. А.; A. S. Goncharova; Гончарова А. С.; A. V. Soldatov; Солдатов А. В.

doi:10.31857/S1028096023030032

Study of Surface Morphology of Microfluidic Chip Channels via X-Ray Tomography and Scanning Electron Microscopy

Authors: Chapek S.V.¹, Pankin I.A.¹, Khodakova D.V.², Guda A.A.¹, Goncharova A.S.², Soldatov A.V.¹
Affiliations:
1. Smart Materials International Research Institute, Southern Federal University
2. National Medical Research Centre for Oncology
Issue: No 3 (2023)
Pages: 92-97
Section: Articles
URL: https://journals.rcsi.science/1028-0960/article/view/137729
DOI: https://doi.org/10.31857/S1028096023030032
EDN: https://elibrary.ru/LGOIBS
ID: 137729

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Abstract
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Abstract

The visualization of microfluidic chips was considered to study morphology of microfluidic channel surface and estimate the quality of 3D printing technology based on digital light processing. The visualization was performed by X-ray microtomography using different iodine-based contrast agents and by scanning electron microscopy. It was shown that X-ray microtomography visualization made it possible to control the quality of device printing relative to geometrical parameters of the models specified at the prototyping stage, as well as to visualize a 3D model of microfluidic channels and surface morphology. The spatial resolution of scanning electron microscopy exceeds the print pixel size and makes it possible to clarify the presence of local defects caused by uneven solidification of the resin during sample washing.

Keywords

microfluidic systems, 3D printing, X-ray tomography, microtomography, scanning electron microscopy.

References

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