The Cognitive Status of Patients After Ischemic Stroke is Associated with the Levels of Cytoplasmic Actin 1 and Some Immunoglobulins in Llcam-Positive Extracellular Vesicles of Blood Serum

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Abstract

Post-stroke cognitive impairment is a significant contributor to disability in people who have had ischemic stroke. Previously, it was shown that the study of the composition of small extracellular vesicles and related functions provides new opportunities for diagnosing post-stroke cognitive impairment. The aim of this work was to compare the proteins of LICAM-positive extracellular vesicles of serum patients with different cognitive status in the acute period of IS. A comparative quantitative proteomic analysis of LICAM-positive extracellular vesicles of patients without cognitive impairment (8, mean age 61.8 ± 14.1 years) and patients with moderate cognitive impairment (MCI) (8, mean age 61.8 ± 14.1 years) revealed significant differences in the levels of 10 proteins out of 131 identified. Patients with MCI, compared to patients without MCI, had reduced levels of proteins associated with the immune system in the acute post-stroke period.

About the authors

M. Yu Zhanina

Moscow Research and Clinical Center for Neuropsychiatry; Department of Functional Biochemistry of Nervous System, Institute of Higher Nervous Activity and Neurophysiology, Russian Academy of Sciences

Moscow, Russia

T. A Druzhkova

Moscow Research and Clinical Center for Neuropsychiatry

Email: druzhkova.tatiana@mail.ru
Moscow, Russia

E. E Vladimirova

M.P. Konchalovsky City Clinical Hospital

Moscow, Russia

A. B Guekht

Moscow Research and Clinical Center for Neuropsychiatry; Pirogov Russian National Research Medical University

Department of Neurology, Neurosurgery and Medical Genetics Moscow, Russia

N. V Gulyaeva

Moscow Research and Clinical Center for Neuropsychiatry; Department of Functional Biochemistry of Nervous System, Institute of Higher Nervous Activity and Neurophysiology, Russian Academy of Sciences

Moscow, Russia

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