Neurochemical Markers of Efficacy of Selective Serotonin Reuptake Inhibitors and Resveratrol in Correcting Anxiety Disorders of Stressful Nature

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Abstract

Anxiety-phobic disorders are behavioral complications of chronic stress. Unfortunately, there is still no effective pharmacological correction of them. The aim of the study was to assess the prospect of the combined use of resveratrol and selective serotonin reuptake inhibitors for the correction of anxiety-phobic disorders caused by chronic predatory stress. To reproduce anxiety-phobic disorders, a model of predatory stress was used, carried out by contact of rats with the smell of a fox. The anxiety level was determined in the elevated cruciform maze test. In the cerebral cortex, the content of serotonin, MAO-A activity and the intensity of lipid peroxidation (POL) were determined. It was found that chronic predatory stress was accompanied by an increase in anxiety, manifested in a decrease in the time spent in the open arms of the cruciform labyrinth and increased freezing. At the same time, serotonin levels and MAO-A activity increased in the brain, and the intensity of lipid peroxidation increased. Fluoxetine and citalopram alone could not effectively correct anxiety-phobic disorders. Resveratrol alone and together with fluoxetine and citalopram could both weaken and enhance anxiety-phobic disorders. The effects of resveratrol were dose-dependent. A decrease in stress anxiety as a result of pharmacological correction was accompanied by a restoration of serotonin levels to control values, a decrease in MAO-A activity and the intensity of POL in the brain. Resveratrol, both independently and in the presence of selective serotonin reuptake inhibitors, can effectively correct anxiety-phobic disorders in some cases and potentiate in others depending on the dose.

About the authors

V. E Tseilikman

Federal State Autonomous Educational Institution South Ural State University (National Research University); Federal State Budgetary Educational Institution of Higher Education “Novosibirsk National Research State University”; Federal State Budgetary Educational Institution of Higher Education “Chelyabinsk State University”

Email: vadimed@yandex.ru
Chelyabinsk, Russia; Novosibirsk, Russia; Chelyabinsk, Russia

O. B Tseilikman

Federal State Autonomous Educational Institution South Ural State University (National Research University); Federal State Budgetary Educational Institution of Higher Education “Chelyabinsk State University”

Chelyabinsk, Russia; Chelyabinsk, Russia

V. A Shatilov

Federal State Budgetary Educational Institution of Higher Education “Chelyabinsk State University”

Chelyabinsk, Russia

G. V Manuilov

Federal State Autonomous Educational Institution South Ural State University (National Research University)

Chelyabinsk, Russia

O. N Egorov

Federal State Budgetary Educational Institution of Higher Education “Chelyabinsk State University”

Chelyabinsk, Russia

M. S Zhukov

Federal State Budgetary Educational Institution of Higher Education “Chelyabinsk State University”

Chelyabinsk, Russia

M. R Aristov

Federal State Budgetary Educational Institution of Higher Education “Chelyabinsk State University”

Chelyabinsk, Russia

A. E Epitashvili

Federal State Budgetary Educational Institution of Higher Education “Chelyabinsk State University”

Chelyabinsk, Russia

D. -M.V Tseylikman

Federal State Budgetary Educational Institution of Higher Education “Chelyabinsk State University”

Chelyabinsk, Russia

I. A Buksha

Federal State Budgetary Educational Institution of Higher Education “Chelyabinsk State University”

Chelyabinsk, Russia

I. A Lipatov

Federal State Budgetary Educational Institution of Higher Education “Chelyabinsk State University”

Chelyabinsk, Russia

M. V Shamshurin

Federal State Budgetary Educational Institution of Higher Education “Chelyabinsk State University”

Chelyabinsk, Russia

A. K Shonina

Federal State Budgetary Educational Institution of Higher Education “Chelyabinsk State University”

Chelyabinsk, Russia

V. A Shevyrin

Federal State Autonomous Educational Institution of Higher Education “Ural Federal University Named After the First President of Russia B.N. Yeltsin”

Yekaterinburg, Russia

A. S Kolesnikova

Federal State Budgetary Educational Institution of Higher Education “Chelyabinsk State University”

Chelyabinsk, Russia

A. A Brichagina

Federal State Budgetary Educational Institution of Higher Education Moscow Institute of Physics and Technology (National Research University)

Moscow, Russia

References

  1. Панин Л.Е., Усенко Г.А. // Тревожность, адаптация и донозологическая диспансеризация. Новосибирск: Наука, 2004. 315 с.
  2. de Boer S.F., Buwalda B., Koolhaas J.M. // Neuroscience & Biobehavioral Reviews. 2017. V. 74. Р. 401–422.
  3. Tye K.M. // Neuron. 2018. V. 100. Р. 436–452.
  4. Saviola F., Pappaianni E., Monti A., Grecucci A., Jovicich J., De Pisapia N. // Scientific Reports. 2020. P. 10–15.
  5. Krupnik V. //. Front Psychol. 2021. V. 81. P.1–11
  6. Staples, L.G. //. 2010. V. 94. Р. 435–445.
  7. Kaplan G.B., Dadhi N.A., Whitaker C.S. //. Frontiers in Physiology. 2023. V. 14. P. 43–58
  8. Calhoon G.G., Tye K.M. // Nature Neuroscience. 2015. V. 18. Р. 1394–1404.
  9. Sreeja V., Jose A., Patel S., Menon B., Athira K.V., Chakravarty S. // Neurochem Int. 2024. V. 173. Р. 105672.
  10. Price C.M., Feduccia A.A., DeBonis K. // J Clin Psychopharmacol. 2022. V. 42. № 5. Р. 464–469.
  11. de Moraes Costa G, Zanatta F.B., Ziegelmann P.K., Soares Barros A.J., Mello C.F. // Pharmacological treatments for adults with post-traumatic stress disorder: A network meta-analysis of comparative efficacy and acceptability. J Psychiatr Res. 2020. V. 130. Р. 412–420.
  12. Belzung C., El Hage W., Moindrot N., Griebel G. // Behavioral and neurochemical changes following predatory stress in mice. Neuropharmacology. 2001. V. 41. № 3. Р. 400–408.
  13. Шишкина Г.Т., Дыгало Н.Н., Юдина А.М., Калинина Т.С., Толстикова Т.Г., Сорокина И.В., Коваленко И.Л., Аникина Л.В. //. Журн. Высш. Нерв. Деят-сти им И. П. Павлова. 2005. Т. 55. № 2. С. 207–212.
  14. Djordjevic J., Djordjevic A., Adzic M., Elaković I., Matić G., Radojcic M.B. // Eur J Pharmacol. 2011. V. 659. № 1. Р. 61–66.
  15. Xie Z., Li P., Lei X., Tang Q., Zhao X., Tang J., He X. //. Chemosphere. 2023. V. 343. Р. 140217.
  16. Soltani D., Azizi B., Rahimi R., Talasaz A.H., Rezaeizadeh H., Vasheghani-Farahani A. // Front. Cardiovasc. Med. 2022. V. 9. Р. 990063.
  17. Garcia-Martinez B.I., Ruiz-Ramos M., Pedraza-Chaverri J., Santiago-Osorio E., Mendoza-Nunez V.M. //. Molecules. 2022. V. 27. Р. 5232.
  18. Mongioi L.M., la Vignera S., Cannarella R., Cimino L., Compagnone M., Condorelli R.A., Calogero A.E. //. Int. J. Mol. Sci. 2021. V. 22. Р. 4362.
  19. Clarke J.O., Mullin G.E. //. Nutr. Clin. Pract. 2008. V. 23. Р. 49–62.
  20. Athar M., Back J.H., Kopelovich L., Bickers D.R., Kim A.L. // Arch. Biochem. Biophys. 2009. V. 486. Р. 95–102.
  21. Islam F., Nafady M.H., Islam M.R., Saha S., Rashid S., Akter A., Or-Rashid M.H., Akhtar M.F., Perveen A., Ashraf M.G., et al. // Mol. Neurobiol. 2022. V. 59. Р. 4384–4404.
  22. Moore A., Beidler J., Hong M. // Molecules. 2018. V. 23. Р. 2197.
  23. Tseilikman V.E., Shatilov V.A., Zhukov M.S., Buksha I.A., Epitashvily A.E., Lipatov I.A., Aristov M.R., Koshelev A.G., Karpenko M.N., Traktirov D.S., Maistrenko V.A., Kamel M., Buhler A.V., Kovaleva E.G., Kalinina T.S., Pashkov A.A., Kon’kov V.V., Novak J., Tseilikman O.B. // Int J Mol Sci. 2023. V. 24. № 18. Р. 14343.
  24. Shih J.H., Ma K.H., Chen C.F., Cheng C.Y., Pao L.H., Weng S.J., Huang Y.S., Shiue C.Y., Yeh M.K., Li I.H. // 2016. V. 26. № 1. Р. 92–104.
  25. Glowinski J., Iversen L.L.// J. Neurochem. 1966. V. 13. № 8. Р. 655–669.
  26. Камышников В.С. // Справочник по клинико-биохимическим исследованиям и лабораторной диагностике. Москва: МЕДпресс-информ, 2009. 896 с.
  27. Москвитина Т.А., Соловьева Н.И. //. Клиническая лабораторная диагностика. 2011. №. 1. С. 3.
  28. Волчегорский И.А. и др. // Экспериментальное моделирование и лабораторная оценка адаптивных реакций организма. Челябинск, 2000. Т. 167.
  29. Bruzsik B., Biro L., Sarosdi K.R., Zelena D., Sipos E., Szebik H., Torok B., Mikics E., Toth M. // Neurobiol Stress. 2021.
  30. Li W., Gu, B., Tao, K., Li, F., Liu, Z., Yao H, Feng D., Liu X. 2019. V. 518. Р. 344–350.
  31. Kmita H., Pinna G., Lushchak V.I. // Front Physiol. 2023. V. 13–14. Р. 1266575.
  32. Handley S.L., McBlane J.W. // Psychopharmacology (Berl). 1993. V. 112. № 1. Р. 13–20.
  33. Mitroshina E.V., Marasanova E.A., Vedunova M.V. // Int J Mol Sci. 2023. V. 24. № 22. Р. 16416.

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