Alloparental Care and Postnatal Development of Heterozygous TPH2 Transgenic Mice

A. A. Kibitkina; Кибиткина А. А.; E. R. Vasilevskaya; Василевская Е. Р.; G. S. Tolmacheva; Толмачева Г. С.; A. M. Zubalii; Зубалий А. М.

doi:10.31857/S1027813323010090

Alloparental Care and Postnatal Development of Heterozygous TPH2 Transgenic Mice

Authors: Kibitkina A.A.¹, Vasilevskaya E.R.¹, Tolmacheva G.S.¹, Zubalii A.M.²
Affiliations:
1. Gorbatov Federal Research Center for Food Systems
2. Scientific Center of Biomedical Technologies of the Federal Medical and Biological Agency of Russia
Issue: Vol 40, No 1 (2023)
Pages: 75-85
Section: Experimental Articles
URL: https://journals.rcsi.science/1027-8133/article/view/142197
DOI: https://doi.org/10.31857/S1027813323010090
EDN: https://elibrary.ru/DUJOQJ
ID: 142197

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Abstract
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Abstract

The issue of the relationship between the transmission of a negative effect from a depressed mother to her offspring is one of the priorities in modern psychiatry. Mice with the knocked-out tryptophan hydroxylase-2 (TPH2) gene have a depressive-compulsive phenotype, which makes these animals a highly appropriate bio-model for studying the role of serotonin in the body. In the offspring of such animals the following reproductive parameters were studied: pups maturation (physiological development) and sensory and motor reflexes. It was found that in the heterozygous mice, maternal care was reduced by the TPH2 gene knockout and canibalism directed at offspring was increased. Deviations and violations in the return of pups to the nest were revealed in maternal behavior. Some deficiency in the development of heterozygous offspring was observed after 10 days. The homozygous (KO) pups had a lower body mass than the heterozygous (Het) and wild-type (Wt) pups. The rate of detachment of the auricle, eruption of the upper incisors, opening of the eyes, and lowering of the testes in the KO pups were observed at the same time as in the Wt and Het pups.

Keywords

brain serotonin, tryptophan hydroxylase-2 (TPH2), mice pups, motor function, sensory reflex, reproduction, breeding

References

Corchs F., Nutt D.J., Corchs F., Hince D.A., Bernik M. et al. // J. Psychopharmacol. 2015. V. 29. P. 61–69.
Pawluski J.L., Li M., Lonstein J.S. // Front. Neuroendocrinol. 2019. V. 53. № 100742. https://doi.org/10.1016/j.yfrne.2019.03.001
Gabriele S., Sacco R., Persico A.M. // Eur. Neuropsychopharmacol. 2014. V. 24. P. 919–929.
Cordner Z.A., Marshall-Thomas I., Boersma G.J., Lee R.S., Potash J.B. et al. // Neurobiol. Stress. 2021. V. 15. №100392.
Migliarini S., Pacini G., Pelosi B., Lunardi G., Pasqualetti M. // Mol. Psychiatry. 2013. V. 18. P. 1106–1118.
Auth C.S., Weidner M.T., Strekalova T., Schmitt-Böhrer A.G., Popp S. et al. // Eur. Neuropsychopharmacol. 2018. V. 12. P. 19–30. https://doi.org/10.1016/j.euroneuro.2018.07.103
Pratelli M., Pasqualetti M. // Biochem. J. 2019. V. 161. P. 3–14.
Angoa-Perez M., Kane M.J., Briggs D.I., Herrera-Mundo N., Sykes C.E. et al. // ACS Chem. Neurosci. 2014. V. 5. № 10. P. 908–919.
Mosienko V., Bert B., Beis D., Matthes S., Fink H. et al. // Transl. Psychiatry. 2012. V. 2. № 122. https://doi.org/10.1038/tp.2012.44
Strekalova T., Svirin E., Waider J., Gorlova A., Cespuglio R. et al. // Prog. Neuropsychopharmacol. Biol. Psychiatry. 2021. V.108. № 110155.
Orso R., Creutzberg K.C., Wearick-Silva L.E., Wendt V.T. et al. // Front. Behav. Neurosci. 2019. V. 13 № 197. https://doi.org/10.3389/fnbeh.2019.00197
Alenina N., Kikic D., Todiras M. et al. // Proc. Natl. Acad. Sci. USA. 2009. V. 106. № 25. P. 10332–10337.
Heyne G., Plisch E.H., Melberg C.G., Sandgren E.P., Peter J.A. et al. // J. Am. Assoc. Lab. Anim. 2015. V. 54. № 4. P. 368–371.
Mironov A.N. // Guidelines for preclinical studies of drugs. M.: Grif and K. M.: Grif and K. 2013. 944 c.
Windsor Z. // Heliyon. 2019. V. 5. № 7. P. 14–28.
Stepanichev M.Y., Nedogreeva O.A, Klimanova M.A. et al. // Neurosci. Behav. Physi. 2022. V. 71. № 3. P. 370–386.
Umemura S., Imai S., Mimura A., Fujiwara M., Ebihara S. // PLoS One. 2015. V. 10. № 8. P. e0136016.
Martin-Sanchez A., Valera-Marin G., Hernandez-Martinez A., Lanuza E., et al. // Front. Neurosci. 2015. V. 9. P. 197–223.
Heyser C.J. // Curr. Protoc. Neurosci. 2004. V. 25. № 8. P. 18.
Pinto L.H., Enroth-Cugell C. // Mamm. Genome. 2000, V. 11. № 7. P. 531–536.
Feather-Schussler D.N., Ferguson T.S. // J. Vis. Exp. 2016. V. 117. P. 1–9.
Yun H., Park E.S., Choi S., Shin B., Yu J. et al. // PLoS Gen. 2019. V. 15 № 6. P. e1008214.
Muzerelle A., Soiza-Reilly M., Hainer C., Ruet P.L. et al. // Sci. Rep. 2021. V. 11. № 1. P. 6004.
Brajon S., Morello G.M., Capas-Peneda S., Hultgren J. et al. // Animals 2021. V. 11. № 8. P. 2327.
Weber E.M., Algers B., Hultgren J., Olsson I.A. // Acta Vet. Scand. 2013. V. 55. № 1. P. 83.
Pelosi B., Migliarini M., Pacini S., Pasqualetti M. // PLoS One. 2015. V. 10. № 8. P. e0136422.
Wolkowitz O.M., Reus V.I., Mellon S.H. // Dialogues in Clinical Neuroscience. 2011. V. 13. № 1. P. 25–39.
Horvath G., Reglodi D., Farkas J., Vadasz G. et al. // Adv. Neurobiol. 2015. V. 10. P. 149–167.
Mosienko V., Alenina N. // Behav. Brain Res. 2018. V. 277. P. 405–420.