Anti cytokine therapy of secondarily-progressing multiple sclerosis (ms)
- Authors: Gusev Е.I.1,2, Demina Т.L.3,2, Boiko А.N.1,2, Buglak А.V.1,2, Belyaeva I.А.1,2, Smirnova N.F.1,2, Alekseeva Т.G.1,2, Pashchenkov М.V.1,2, Skurkovich В.1,2, Kelly D.1,2, Skurkovic S.V.1,2
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Affiliations:
- Russian State Medical University
- ABC Labs
- Российский государственный медицинский университет
- Issue: Vol XXIX, No 1-2 (1997)
- Pages: 55-58
- Section: Articles
- URL: https://journals.rcsi.science/1027-4898/article/view/79894
- DOI: https://doi.org/10.17816/nb79894
- ID: 79894
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Abstract
For treating active forms of secondarily-progressing multiple sclerosis a preliminary clinical trial was performed by two courses: antibody-to-cytokine course (γINT, αINT and TNFα) and cyclosporin А-course (sandimmun). Data of preliminary test of antibodies to cytokines evidence to possibility of performing further clinical trials "antibodies to γINT and to TNFα (to a lesser degree)" during active forms of progressive MS. Were obtained the results, evidencing to a possible use of sandimmun in constantly progressive forms of secondarily progressing disease, when favourable clinical effect coincided with supression of cytokine IL-2 production and lowering of activeness of immunocytes.
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##article.viewOnOriginalSite##About the authors
Е. I. Gusev
Russian State Medical University; ABC Labs
Author for correspondence.
Email: info@eco-vector.com
Russian Federation, Moscow; Rockville, USA
Т. L. Demina
Российский государственный медицинский университет; ABC Labs
Email: info@eco-vector.com
Russian Federation, Москва; Роквил, США
А. N. Boiko
Russian State Medical University; ABC Labs
Email: info@eco-vector.com
Russian Federation, Moscow; Rockville, USA
А. V. Buglak
Russian State Medical University; ABC Labs
Email: info@eco-vector.com
Russian Federation, Moscow; Rockville, USA
I. А. Belyaeva
Russian State Medical University; ABC Labs
Email: info@eco-vector.com
Russian Federation, Moscow; Rockville, USA
N. F. Smirnova
Russian State Medical University; ABC Labs
Email: info@eco-vector.com
Russian Federation, Moscow; Rockville, USA
Т. G. Alekseeva
Russian State Medical University; ABC Labs
Email: info@eco-vector.com
Russian Federation, Moscow; Rockville, USA
М. V. Pashchenkov
Russian State Medical University; ABC Labs
Email: info@eco-vector.com
Russian Federation, Moscow; Rockville, USA
В. Skurkovich
Russian State Medical University; ABC Labs
Email: info@eco-vector.com
Russian Federation, Moscow; Rockville, USA
D. Kelly
Russian State Medical University; ABC Labs
Email: info@eco-vector.com
United States, Moscow; Rockville, USA
S. V. Skurkovic
Russian State Medical University; ABC Labs
Email: info@eco-vector.com
Russian Federation, Moscow; Rockville, USA
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