Email this article FOLATE METABOLISM GENETIC POLYMORPHISM MTHFR 677C> T AND CATATONIC SYMPTOMS OF SCHIZOPHRENIA
- Authors: Zhilyaeva T.V1, Sergeeva A.V1, Blagonravova A.S1, Akimova E.V1, Kasimova L.N1
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Affiliations:
- Nizhny Novgorod State Medical Academy
- Issue: Vol XLVIII, No 2 (2016)
- Pages: 12-16
- Section: Articles
- URL: https://journals.rcsi.science/1027-4898/article/view/13977
- DOI: https://doi.org/10.17816/nb13977
- ID: 13977
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Abstract
Folate metabolism disturbances, including the thylenetetrahydrofolatereductase (MTHFR) 677C>T genetic polymorphism, is currently being studied in relation to various aspects of schizophrenia. It has been shown that carriage of the polymorphism MTHFR 677C> T is associated with the severity of the negative and cognitive symptoms. The carriage of this polymorphism leads to hyperhomocysteinemia and methionine deficiency. According to several studies, both factors can make an independent contribution to the etiopathogenesis of schizophrenia. The relationship of folate metabolism disturbances with catatonic schizophrenia symptoms was not investigated up to date. In this regard, the aim of this study was the comparative analysis of the severity of catatonic symptoms in samples of schizophrenia patients with carriage of different MTHFR C677T genotypes based on standardized clinical assessment with rating scales. 150 patients with a diagnosis of schizophrenia were examined for the presence of polymorphisms MTHFR677C>T. A number of patients were examined using the Scale for the Assessment of Positive and Negative syndromes of schizophrenia (hereinafter PANSS, n = 52), the Scale for the Assessment of Negative symptoms of schizophrenia (hereinafter SANS, n = 64) as well as the Calgary Depression Scale for Schizophrenia (hereinafter CDSS, n = 62). Some items of PANSS and SANS reflect the presence of catatonic symptoms in patient, according to the literature. Therefore, they were used to assess the severity of catatonia. Patients with carriage of polymorphism MTHFR 677C>T (n = 77) in contrast to the normal genotype MTHFR677CC carriers (n = 73) have a greater severity of separate PANSS and SANS items, relating to catatonia, and the total score of catatonic symptoms. The differences are not related to gender, age of the patients and the duration of their disease, as well as the presence of their depressive symptoms as measured by CDSS and the factor “anxiety-depression” of PANSS. The results indicate the need for further study of the association of folate metabolism disturbances (including polymorphism MTHFR677C>T) with catatonic schizophrenia symptoms using standardized catatonia rating scales.
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##article.viewOnOriginalSite##About the authors
Tatiana V Zhilyaeva
Nizhny Novgorod State Medical Academy
Email: bizet@inbox.ru
кафедра психиатрии и медицинcкой психологии 603005, Nizhny Novgorod, Minin and Pozharsky sq., 10/1
Angelika V Sergeeva
Nizhny Novgorod State Medical Academy
Email: bizet@inbox.ru
кафедра психиатрии и медицинcкой психологии 603005, Nizhny Novgorod, Minin and Pozharsky sq., 10/1
Anna S Blagonravova
Nizhny Novgorod State Medical Academy
Email: bizet@inbox.ru
кафедра психиатрии и медицинcкой психологии 603005, Nizhny Novgorod, Minin and Pozharsky sq., 10/1
Elena V Akimova
Nizhny Novgorod State Medical Academy
Email: bizet@inbox.ru
кафедра психиатрии и медицинcкой психологии 603005, Nizhny Novgorod, Minin and Pozharsky sq., 10/1
Lala N Kasimova
Nizhny Novgorod State Medical Academy
Email: bizet@inbox.ru
кафедра психиатрии и медицинcкой психологии 603005, Nizhny Novgorod, Minin and Pozharsky sq., 10/1
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