Comt val158met genotype affects mu-opioid neurotransmitter responses to a pain stressor (Science. — 2003. —Feb. 21. — 299(5610). — P. 1240—1243: англ.)
- Authors: Zubieta J.1, Heitzeg M.1, Smith Y.1, Bueller J.1, Xu K.1, Xu Y.1, Коерре R.1, Stohler C.1, Goldman D.1
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Affiliations:
- University of Michigan
- Issue: Vol XXXV, No 1-2 (2003)
- Pages: 78-78
- Section: Abstracts
- URL: https://journals.rcsi.science/1027-4898/article/view/89679
- DOI: https://doi.org/10.17816/nb89679
- ID: 89679
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Abstract
The catechol-O-methyl-transferase (COMT) gene regulates the metabolic processes of the neurotransmitter dopamine and, through it, influences endorphins, which play an important role in the process of pain perception. It was found that the COMT gene with the amino acid valine (val158) is more active than the variant of the gene containing methionine (met158).
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##article.viewOnOriginalSite##About the authors
J. Zubieta
University of Michigan
Author for correspondence.
Email: info@eco-vector.com
Department of Psychiatry and Mental Health Research Institute
United States, MichiganM. Heitzeg
University of Michigan
Email: info@eco-vector.com
Department of Psychiatry and Mental Health Research Institute
United States, MichiganY. Smith
University of Michigan
Email: info@eco-vector.com
Department of Psychiatry and Mental Health Research Institute
United States, MichiganJ. Bueller
University of Michigan
Email: info@eco-vector.com
Department of Psychiatry and Mental Health Research Institute
United States, MichiganK. Xu
University of Michigan
Email: info@eco-vector.com
Department of Psychiatry and Mental Health Research Institute
United States, MichiganY. Xu
University of Michigan
Email: info@eco-vector.com
Department of Psychiatry and Mental Health Research Institute
United States, MichiganR. Коерре
University of Michigan
Email: info@eco-vector.com
Department of Psychiatry and Mental Health Research Institute
United States, MichiganC. Stohler
University of Michigan
Email: info@eco-vector.com
Department of Psychiatry and Mental Health Research Institute
United States, MichiganD. Goldman
University of Michigan
Email: info@eco-vector.com
Department of Psychiatry and Mental Health Research Institute
United States, Michigan