Clinical and immunological indications of diffuse connective tissue diseases in patients with multiple sclerosis

Cover Page

Cite item

Full Text

Abstract

Discovered at multiple sclerosis the disturbance of operation of an immune system in many respects are similar to defects at a number classical autoimmune diseases. In the patients with multiple sclerosis are revealed by us the clinical indications close to those at diffuse connective tissue diseases, in particular, at system scleroderma. It was investigated the levels of serum autoantibodies to native and denature DNA in multiple sclerosis and system scleroderma. It was discovered the association of the increased levels of autoantibodies to DNA and the first stage of multiple sclerosis. The data, obtained by us, testify to a generality pathogenesis of multiple sclerosis and autoimmune connective tissue diseases at early stages of their origin with a further divergence of paths of their development.

About the authors

I. V. Sultanova

Kazan State Medical University; Kazan State University; Central Research Laboratory of Kazan State Medical Academy

Author for correspondence.
Email: info@eco-vector.com
Russian Federation, Kazan; Kazan; Kazan

Yu. O. Kolikova

Kazan State Medical University; Kazan State University; Central Research Laboratory of Kazan State Medical Academy

Email: info@eco-vector.com
Russian Federation, Kazan; Kazan; Kazan

D. G. Ishmuhametova

Kazan State Medical University; Kazan State University; Central Research Laboratory of Kazan State Medical Academy

Email: info@eco-vector.com
Russian Federation, Kazan; Kazan; Kazan

T. V. Matveeva

Kazan State Medical University; Kazan State University; Central Research Laboratory of Kazan State Medical Academy

Email: info@eco-vector.com
Russian Federation, Kazan; Kazan; Kazan

M. I. Arleevskaya

Kazan State Medical University; Kazan State University; Central Research Laboratory of Kazan State Medical Academy

Email: info@eco-vector.com
Russian Federation, Kazan; Kazan; Kazan

References

  1. Барановский А.Г., Канышкова Т.Г., Могельницкий А.С. и др. // Биохимия. — 1998. — 63 (11) — С. 1459—1469.
  2. Матвеева Т.В., Арлеевская М.И., Демин Т.В // Неврол. вести. — 1998. — № 3—4. — С. 60—64.
  3. Насонова В.А., Бунчук Н.В. Ревматические болезни. — М., 1997.
  4. Саттарова Л.И., Гафиятуллина Л.А., Аглиуллина Д.Г., Винтер В.Г. //Биотехнология. —1994. —№ 11—12. — С. 38—41.
  5. Allinquant В., Schuller Е. // Pathol. Biol. (Paris) — 1987. — Vol. 35 (3). — P. 291—298.
  6. Kira J., Goto I. // J. Neurol. Neurosurg Psychiatry. — 1994. — Vol. 57 (9). — P. 1124—1125.
  7. Poser C.M., Party D.W., Scheinberg L. et al. // Ann. Neurol. — 1983. — Vol. 13 (2). — Vol. 227—231.
  8. Williamson R.A., Burgoon M.P., Owens G.P. et al. // Proc. Natl. Acad. Sci. USA. — 2001. Vol 98 (4). —P. 1793—1798.

Supplementary files

Supplementary Files
Action
1. JATS XML
2. Fig. 1

Download (119KB)
3. Fig. 2

Download (106KB)

Copyright (c) 2003 Sultanova I.V., Kolikova Y.O., Ishmuhametova D.G., Matveeva T.V., Arleevskaya M.I.

Creative Commons License
This work is licensed under a Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International License.

This website uses cookies

You consent to our cookies if you continue to use our website.

About Cookies