Clinical spectrum of frontotemporal dementia: schizophrenia-like symptoms and amyotrophic lateral sclerosis (family case study)

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Abstract

Frontotemporal dementia is a heterogeneous pathology with various clinical, histological, and genetic variants. The behavioral variant of frontotemporal dementia (bvFTD) in some cases presents differential diagnostic difficulties when distinguishing from primary mental disorders. The article provides an observation of patient K., who was observed at the initial stage of the disease with a diagnosis of schizophrenia. The comparison of psychopathological and behavioral symptoms with the presence of a family history of amyotrophic lateral sclerosis (ALS) served as a turning point to a different interpretation of the pathology and recognition and confirmation of the “definite diagnosis” — bvFTD.

About the authors

Elena G. Mendelevich

Kazan State Medical University

Author for correspondence.
Email: emendel@mail.ru
ORCID iD: 0000-0002-6829-7942
SPIN-code: 5970-6926

MD, Dr. Sci. (Med.), Professor

Russian Federation, Kazan

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2. Fig. 1. Magnetic resonance imaging of the brain in the sagittal plane (a) and axial plane (b): signs of marked atrophy (predominantly frontal and temporal).

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