A clinical case of ischemic stroke in a young patient with thrombophilia
- Authors: Minina J.D.1, Strelnikova I.A.1, Svetkina A.A.2,3, Kalinin V.A.3
-
Affiliations:
- Samara Regional Clinical Hospital named after V.D. Seredavin
- Regional Clinical Hospital named after V.D. Seredavin
- Samara State Medical University
- Issue: Vol LII, No 2 (2020)
- Pages: 102-104
- Section: Наблюдения из практики
- URL: https://journals.rcsi.science/1027-4898/article/view/16456
- DOI: https://doi.org/10.17816/nb16456
- ID: 16456
Cite item
Abstract
A clinical observation is presented of a young patient with a rare form of homozygous mutation, which caused recurrent pulmonary embolism, ischemic stroke in the left middle cerebral artery basin. To determine the etiology of recurrent thrombosis, instrumental diagnostic methods were performed to exclude dissection of extra- and intracranial arteries, heart diseases, as well as laboratory methods to detect thrombophilia, antiphospholipid syndrome, connective tissue diseases, and the blood system. According to the results of the examination, the patient revealed a homozygous mutation of the plasminogen activator inhibitor PAI-1, which, in the absence of other factors, can be considered as a probable cause of recurrent thrombosis. During treatment, the patient’s condition improved, focal neurological symptoms partially regressed. As a secondary prophylaxis, the patient was prescribed lifelong administration of warfarin under the control of INR.
Full Text
##article.viewOnOriginalSite##About the authors
Julia D. Minina
Samara Regional Clinical Hospital named after V.D. Seredavin
Author for correspondence.
Email: jminina1988@gmail.com
Russian Federation, 443095, Samara, Tashkentskаya str, 159
Inna A. Strelnikova
Samara Regional Clinical Hospital named after V.D. Seredavin
Email: jminina1988@gmail.com
Russian Federation, 443095, Samara, Tashkentskаya str, 159
Anastasia A. Svetkina
Regional Clinical Hospital named after V.D. Seredavin; Samara State Medical University
Email: jminina1988@gmail.com
Russian Federation, 443095, Samara, Tashkentskаya str, 159; 443079, Samara, Chapaevskaya str, 89
Vladimir A. Kalinin
Samara State Medical University
Email: jminina1988@gmail.com
Russian Federation, 443079, Samara, Chapaevskaya str, 89
References
- Пизова Н.В. Тромбофлии: генетические полиморфизмы и сосудистые катастрофы. М.: ИМА-ПРЕСС. 2013; 248 с. [Pizova N.V. Thrombophilia: genetic polymorphisms and vascular catastrophes. M.: IMA-PRESS. 2013; 248 p.]
- Franchini M., Veneri D., Salvagno G. et al. Inherited thrombophilia. Crit. Rev. Clin. Lab. Sci. 2006; 43 (3): 249–290. DOI: 0.1080/10408360600552678.
- Manucci P.M. The molecular basis of inherited thrombophilia. Vox. Sang. 2000; 78: 39–45.
- Cazenave J., Gachet C. ADP-receptor activation and platelet aggregation. Pharmacol. Res. 1995; 31: 291–291. doi: 10.1016/1043-6618(95)87424-0.
- Folsom A. Hemostatic risk factors for atherothrombotic disease: An epidemiologic view. Thrombosis and Haemostasis. 2001; 86 (07): 366–373. doi: 10.1055/s-0037-1616234.
- Руксин В.В. Тромбозы в кардиологической практике. СПб.: Невский Диалект. М.: Бином. 1998; 126 с. [Ruxin V.V. Thrombosis in cardiology practice. St. Petersburg: Nevsky Dialect. M.: Binom. 1998; 126 p.]
- Шиффман Ф.Дж. Патофизиология крови. Пер. с англ. Под ред. Ю.В. Наточина. М.: Бином. 2001; 446 с. [Schiffman F.J. Pathophysiology of blood. Per. from English ed. Yu.V. Sharpening. M.: Binom. 2001; 446 p.]
- Баркаган З.С. Учение о тромбофилиях на современном этапе. Consil. med. 2000; 6: 61–65. [Barkagan Z.S. The doctrine of thrombophilia at the present stage. Consil. med. 2000; 6: 61–65.]