Cerebral amyloid angiopathy and hypertensive cerebral microangiopathy. Differential diagnosis

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Abstract

Cerebral amyloid angiopathy (CAA) and hypertensive small vessel disease (HTN-SVD) have a number of similar clinical manifestations, but the prognosis, treatment and approaches to the stroke prevention in patients with these diseases are different, so the differential diagnosis is of great importance. This review discusses the most discriminative clinical signs of CAA, such as «amyloid spells», convexital subarachnoid hemorrhages, clinical manifestations of lobar hematomas and microbleedings. Important neuroimaging differences of CAA from HTN-SVD are cortical superficial siderosis, convexital subarachnoid hemorrhages, cortical microbleedings, «lobar» lacunes, expansion of perivascular spaces in semi-oval centrum, white matter hyperintensity in posterior brain regions.

About the authors

Оksana А. Novosadova

Volga-region Research Medical University

Author for correspondence.
Email: novosadova_o_a@mail.ru
Russian Federation, 603005, Nizhny Novgorod, Мinin and Pozharsky square, 10/1

Vera N. Grigorjeva

Volga-region Research Medical University

Email: novosadova_o_a@mail.ru
Russian Federation, 603005, Nizhny Novgorod, Мinin and Pozharsky square, 10/1

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Copyright (c) 2019 Novosadova О.А., Grigorjeva V.N.

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