CLINICO-PSYCHOPATHOLOGICAL AND IMMUNOLOGICAL TYPES OF MANIC-PARAPHRENIC FORMS IN THE FRAMEWORK OF PAROXYSMAL COURSES OF ENDOGENOUS PSYCHOSES

In the present study 73 patients with manic-paraphrenic form developed within the framework of the paroxysmal course of endogenous psychoses were examined. It is established that in manic-paraphrenic psychoses not only inflammatory but also autoimmune reactions are triggered, reflecting the severity of the current pathological process in the Central nervous system. After a thorough psychopathological analysis of the mechanisms of delirium and their relationships with manic affect, 3 types of the studied States were identified. At type 1, there was a moderate increase in the activity of inflammatory markers. In patients of type 2, a marked increase in the activity of inflammatory markers was revealed. Increased activity of both inflammatory and autoimmune markers was revealed in patients of type 3. Taking into account the obtained data, it was found that the level of activation of the immune system, including inflammatory (the activity of leukocyte elastase and а1-proteinase inhibitor) and autoimmune markers (the level of autoantibodies to the neuroantigen S100-B) increases with the aggravation of psychopathological symptoms and is an unfavorable factor in terms of the further course of the disease.

mania, paraphrenia, endogenous psychosis, inflammatory markers, leukocyte elastase