Rho/ROCK signaling pathway after spinal cord injury
- Authors: Chelyshev Y.A1, Ismagilov M.F1, Mukhamedshina Y.O1, Povysheva T.V1, Boychuk N.V1
-
Affiliations:
- Kazan State medical university
- Issue: Vol XLIX, No 3 (2017)
- Pages: 71-77
- Section: Articles
- URL: https://journals.rcsi.science/1027-4898/article/view/14092
- DOI: https://doi.org/10.17816/nb14092
- ID: 14092
Cite item
Full Text
Abstract
Full Text
##article.viewOnOriginalSite##About the authors
Yuri A Chelyshev
Kazan State medical university
Email: chelyshev-kzn@yandex.ru
Butlerov str., 49, Kazan, 420012
Maksum F Ismagilov
Kazan State medical universityButlerov str., 49, Kazan, 420012
Yana O Mukhamedshina
Kazan State medical universityButlerov str., 49, Kazan, 420012
Tatyana V Povysheva
Kazan State medical universityButlerov str., 49, Kazan, 420012
Natalya V Boychuk
Kazan State medical universityButlerov str., 49, Kazan, 420012
References
- Челышев Ю.А., Шаймарданова Г.Ф., Мухамедшина Я.О., Нигметзянова М.В. Глиальные барьеры при травме спинного мозга как мишень генно-клеточной терапии // Неврологический вестник. 2013. Т. 45, №1. С. 87-93.
- Anderson M.A., Burda J.E., Ren Y. et al. Astrocyte scar formation aids CNS axon regeneration // Nature. 2016. Vol. 532. P. 195-200.
- Baer A.S., Syed Y.A., Kang S.U. et al. Myelin-mediated inhibition of oligodendrocyte precursor differentiation can be overcome by pharmacological modulation of Fyn-RhoA and protein kinase C signaling // Brain. 2009. Vol. 132. P. 465-481.
- Cahoy J.D., Emery B., Kaushal A. et al. A transcriptome database for astrocytes, neurons, and oligodendrocytes: A new resource for understanding brain development and function // J. Neurosci. 2008. № 28. P. 264-278.
- Challagundla M., Koch J.C., Ribas V.T. et al. AAV-mediated expression of BAG1 and ROCK2-shRNA promote neuronal survival and axonal sprouting in a rat model of rubrospinal tract injury // J Neurochem. 2015. Vol. 134, № 2. P. 261-275.
- Chen C., Yu J.Z., Zhang Q. et al. Role of Rho Kinase and Fasudil on Synaptic Plasticity in Multiple Sclerosis // Neuromolecular. Med. 2015. Vol. 17, № 4. P. 454-465.
- Chiba Y., Kuroda S., Shichinohe H., et al. Synergistic effects of bone marrow stromal cells and a Rho kinase (ROCK) inhibitor, fasudil on axon regeneration in rat spinal cord injury // Neuropathology. 2010. Vol. 30, № 3. P. 241-250.
- Chung W.F., Liu S.W., Chang P.Y. et al. Hyperlipidemia and statins affect neurological outcome in lumbar spine injury // Int. J. Environ. Res. Public Health. 2015. Vol. 12, № 1. P. 402-413.
- Ding S., Bao Y., Lin Y. et al. Neuroprotective effect of functionalized multi-walled carbon nanotubes on spinal cord injury in rats // Int. J. Clin. Exp. Pathol. 2015. Vol. 8, № 12. P. 15769-15777.
- Ding J., Yu J.Z., Li Q.Y. et al. Rho kinase inhibitor Fasudil induces neuroprotection and neurogenesis partially through astrocyte-derived G-CSF // Brain Behav. Immun. 2009. Vol.23. P. 1083-1088.
- Drummond E.S., Rodger J., Penrose M. et al. Effects of intravitreal injection of a Rho-GTPase inhibitor (BA-210), or CNTF combined with an analogue of cAMP, on the dendritic morphology of regenerating retinal ganglion cells // Restor. Neurol. Neurosci. 2014. Vol. 32. P. 391-402.
- Dubreuil C.I., Winton M.J., McKerracher L. Rho activation patterns after spinal cord injury and the role of activated Rho in apoptosis in the central nervous system // J. Cell Biol. 2003. Vol. 162. P. 233-243.
- Erschbamer M.K., Hofstetter C.P., Olson L. RhoA, RhoB, RhoC, Rac1, Cdc42, and Tc10 mRNA levels in spinal cord, sensory ganglia, and corticospinal tract neurons and long-lasting specific changes following spinal cord injury // J. Comp. Neurol. 2005. Vol. 484. P. 224-233.
- Furuya T., Hashimoto M., Koda M., et al. Treatment of rat spinal cord injury with a Rho-kinase inhibitor and bone marrow stromal cell transplantation // Brain Res. 2009. №. 1295. P. 192-202.
- Gao S., Zhang Z.M., Shen Z.L. et al. Atorvastatin activates autophagy and promotes neurological function recovery after spinal cord injury // Neural. Regen. Res. 2016. Vol. 11, № 6. P. 977-982.
- Gwak S.J., Macks C., Jeong D.U. et al. RhoA knockdown by cationic amphiphilic copolymer/siRhoA polyplexes enhances axonal regeneration in rat spinal cord injury model // Biomaterials. 2017. № 121. P. 155-166.
- Hou X.L., Chen Y., Yin H., Duan W.G. Combination of fasudil and celecoxib promotes the recovery of injured spinal cord in rats better than celecoxib or fasudil alone // Neural Regen. Res. 2015. Vol. 10, №. 11. P. 1836-1840.
- Huang S.Y., Sung C.S., Chen W.F. et al. Involvement of phosphatase and tensin homolog deleted from chromosome 10 in rodent model of neuropathic pain // J. Neuroinflammation. 2015. Vol. 12. P. 59.
- Imai F., Ladle D.R., Leslie J.R. et al. Synapse Formation in Monosynaptic Sensory-Motor Connections Is Regulated by Presynaptic Rho GTPase Cdc42 // J. Neurosci. 2016. Vol. 36, №. 21. P. 5724-5735.
- Kahveci R., Gökçe E.C., Gürer B. et al. Neuroprotective effects of rosuvastatin against traumatic spinal cord injury in rats // Eur. J. Pharmacol. 2014. № 741. P. 45-54.
- Kesherwani V., Tarang S., Barnes R., Agrawal S.K. Fasudil reduces GFAP expression after hypoxic injury // Neurosci. Lett. 2014. № 576. P. 45-50.
- Kopp M.A., Liebscher T., Watzlawick. R. et al. SCISSOR-Spinal Cord Injury Study on Small molecule-derived Rho inhibition: a clinical study protocol // BMJ Open. 2016. Vol. 6, № 7.
- Lau C.L., O’Shea R.D., Broberg B.V. et al. The Rho kinase inhibitor Fasudil up-regulates astrocytic glutamate transport subsequent to actin re-modelling in cultured murine astrocytes // Br. J. Pharmacol. 2011. № 163. P. 533-545.
- Le Comte M.D., Shimada I.S., Sherwin C., Spees J.L. Notch1-STAT3-ETBR signaling axis controls reactive astrocyte proliferation after brain injury // Proc. Natl. Acad. Sci. USA. 2015. № 112. P. 8726-8731.
- Li Y.H., Yu J.W., Xi J.Y. et al. Fasudil enhances therapeutic efficacy of neural stem cells in the mouse model of MPTP-induced Parkinson’s disease // Mol. Neurobiol. 2016. [Epub ahead of print].
- Liu Y.H., Zhao Y., Huang F.Z. et al. Combination of early constraint-induced movement therapy and fasudil enhances motor recovery after ischemic stroke in rats // Int. J. Neurosci. 2016. Vol. 126. № 2. P. 168-173.
- Lord-Fontaine S., Yang F., Diep Q. et al. Local inhibition of Rho signaling by cell-permeable recombinant protein BA-210 prevents secondary damage and promotes functional recovery following acute spinal cord injury // J. Neurotrauma. 2008. №. 11. P. 1309-1322.
- Mattila P.K., Lappalainen P. Filopodia: Molecular architecture and cellular functions // Nat. Rev. Mol. Cell Biol. 2008. № 9. P. 446-454.
- McKerracher L., Anderson K.D. Analysis of recruitment and outcomes in the phase I/IIa Cethrin clinical trial for acute spinal cord injury // J Neurotrauma. 2013. № 30. P. 1795-1804.
- Mironova Y.A., Giger R.J. Where no synapses go: gatekeepers of circuit remodeling and synaptic strength // Trends Neurosci. 2013. № 6. P. 363-373.
- Murk K., Blanco Suarez E.M., Cockbill L.M., et al. The antagonistic modulation of Arp2/3 activity by N-WASP, WAVE2 and PICK1 defines dynamic changes in astrocyte morphology // J. Cell Sci. 2013, № 126. P. 3873-3883.
- Nazli Y., Colak N., Alpay M.F. et al. Neuroprotective effect of atorvastatin in spinal cord ischemia-reperfusion injury // Clinics (Sao Paulo). 2015. № 1. P. 52-60.
- Newell-Litwa K.A., Badoual M., Asmussen H., et al. ROCK1 and 2 differentially regulate actomyosin organization to drive cell and synaptic polarity // J. Cell. Biol. 2015. Vol. 210. № 2. P. 225-242.
- O’Shea R.D., Lau C.L., Zulaziz N.B. et al. Transcriptomic analysis and 3D bioengineering of astrocytes indicate ROCK inhibition produces cytotrophic astrogliosis // Front. Neurosci. 2015. № 9. P. 50.
- Pedraza C.E., Taylor C., Pereira A. et al. Induction of oligodendrocyte differentiation and in vitro myelination by inhibition of rho-associated kinase // ASN Neuro. 2014. Vol. 6. № 4.
- Robin N.C., Agoston Z., Biechele T.L. et al. Simvastatin promotes adult hippocampal neurogenesis by enhancing Wnt/β-catenin signaling // Stem Cell Reports. 2013. Vol. 2. № 1. P. 9-17.
- Roloff F., Scheiblich H., Dewitz C. et al. Enhanced neurite outgrowth of human model (NT2) neurons by small-molecule inhibitors of Rho/ROCK signaling // PLoS One. 2015. Vol. 10. №. 2.
- Sagawa H., Terasaki H., Nakamura M. et al. A novel ROCK inhibitor, Y-39983, promotes regeneration of crushed axons of retinal ganglion cells into the optic nerve of adult cats // Exp. Neurol. 2007. № 1. P. 230-240.
- Sheean R.K., Lau C.L., Shin Y.S. et al. Links between L-glutamate transporters, Na+/K+-ATPase and cytoskeleton in astrocytes: Evidence following inhibition with rottlerin // Neuroscience. 2013. № 254. P. 335-346.
- Sohn H.M., Hwang J.Y., Ryu J.H. et al. Simvastatin protects ischemic spinal cord injury from cell death and cytotoxicity through decreasing oxidative stress: in vitro primary cultured rat spinal cord model under oxygen and glucose deprivation-reoxygenation conditions // J. Orthop. Surg. Res. 2017. Vol. 12. № 1. P. 36.
- Swanger S.A., Mattheyses A.L., Gentry E.G., Herskowitz J.H. ROCK1 and ROCK2 inhibition alters dendritic spine morphology in hippocampal neurons // Cell. Logist. 2016. Vol. 5. №. 4.
- Tarabal O., Caraballo-Miralles V., Cardona-Rossinyol A. et al. Mechanisms involved in spinal cord central synapse loss in a mouse model of spinal muscular atrophy // J. Neuropathol. Exp. Neurol. 2014. Vol. 73. № 6. P. 519-535.
- Tokushige H., Inatani M., Nemoto S. et al. Effects of topical administration of y-39983, a selective rho-associated protein kinase inhibitor, on ocular tissues in rabbits and monkeys // Invest. Ophthalmol. Vis. Sci. 2007. Vol. 48. № 7. P. 3216-3122.
- Watzlawick R., Sena E.S., Dirnag U. et al. Effect and reporting bias of RhoA/ROCK-blockade intervention on locomotor recovery after spinal cord injury: a systematic review and meta-analysis // JAMA Neurol. 2014. Vol. 71. № 1. P. 91-99.
- Wennerberg K., Rossman K.L., Der C.J. The Ras superfamily at a glance // J. Cell. Sci. 2005. Vol. 1. № 118. P. 843-846.
- Williams M.R., DeSpenza T.Jr., Li M. et al. Hyperactivity of newborn Pten knock-out neurons results from increased excitatory synaptic drive // J. Neurosci. 2015. Vol. 35. № 3. P. 943-959.
- Yano K., Kawasaki K., Hattori T. et al. Demonstration of elevation and localization of Rho-kinase activity in the brain of a rat model of cerebral infarction // Eur. J. Pharmacol. 2008. № 594. P. 77-83.
- Yu J.W., Li Y.H., Song G.B. et al. Synergistic and superimposed effect of bone marrow-derived mesenchymal stem cells combined with fasudil in experimental autoimmune encephalomyelitis // J. Mol. Neurosci. 2016. Vol. 60. № 4. P. 486-497.
- Yu J.Z., Chen C., Zhang Q. et al. Changes of synapses in experimental autoimmune encephalomyelitis by using Fasudil // Wound Repair Regen. 2016. Vol. 24. № 2. P. 317-327.
- Zhang C., Wu J.M., Liao M. et al. The ROCK/GGTase pathway are essential to the proliferation and differentiation of neural stem cells mediated by simvastatin // J. Mol. Neurosci. 2016. Vol. 60. № 4. P. 474-485.