Email this article METHODS OF OBJECTIVE CONTROL OF THE THERAPY EFFECTIVENESS IN CHILDREN WITH TICS
- Authors: Zykov V.P1, Kashirina E.A2, Naugolnykh J.V2
-
Affiliations:
- Russian medical academy of post-graduate education
- Children municipal polyclinic № 110
- Issue: Vol XLVIII, No 2 (2016)
- Pages: 35-41
- Section: Articles
- URL: https://journals.rcsi.science/1027-4898/article/view/13986
- DOI: https://doi.org/10.17816/nb13986
- ID: 13986
Cite item
Full Text
Abstract
In 43 patients with tics at the age of 10-17 there was studied effectiveness of hopantenic acid usage in doses 500 mg x 3 daily during 6 weeks to correct their hyperkinesias. The therapy effectiveness was evaluated by Yale Global Tic Severity Scale (YGTSS). Hopantenic acid therapy significantly decreased the amplitude of somatosensory cortex evaluated by somatosensory evoked potentials method, normalized the situational and personal anxiety evaluated by Spielberg-Hanin scale. Therapy by hopantenic acid reliable decreased the summary severity of tics (р<0,03, p<0,02 in different groups of patients), defined by Yale scale (method of tics counting for 20 minutes), manifestations of situational anxiety (p<0,001; p<0,03), and increased volume of single aural-speech memory (p<0,01; p<0,05). Hopantenic acid therapy significantly decreased the amplitude of somatosensory cortex evaluated by somatosensory evoked potentials method (p<0,001; p<0,03). The technique of somatosensory evoked potentials using Yale scale for evaluation of the severity of tics can be used as an objective method to control the therapy.
Full Text
##article.viewOnOriginalSite##About the authors
Valery P Zykov
Russian medical academy of post-graduate educationdepartment of childish neurology 125993, Моscow, Barrikadny street, 2/1
Elmira A Kashirina
Children municipal polyclinic № 110127490, Моscow, Dekabristov street, 39
Julia V Naugolnykh
Children municipal polyclinic № 110
Email: julia-nv@mail.ru
127490, Моscow, Dekabristov street, 39
References
- Антонов И.П., Шанько Г.Г. Гиперкинезы у детей. В кн.: вопросы этиологии, патогенеза, лечения. Минск: Наука и техника, 1975. 213 с.
- Будкевич А.В. Нейрофизиологические методы коррекции тикозных гиперкинезов у детей: дисс.. канд. мед. наук. М.: ГОУДПО «Российская медицинская академия последипломного образования», 2007. 113 с.
- Вассерман Л.И., Дорофеева С.И., Меерсон Я.А. Методы нейропсихологической диагностики. Практическое руководство. СПб: Стройдеспечать, 1997.
- Воронина Т.А. Фармакология ноотропов. М., 1989. С. 8-19.
- Гнездицкий В.В., Корепина О.С Атлас по вызванным потенциалам мозга. Иваново: ПрессСто, 2011. 532 с.
- Зенков Л.Р., Ронкин М.А. Функциональная диагностика нервных заболеваний. М.: МЕДпресс-информ», 2011. 488 с.
- Зыков В.П. Тики детского возраста. М.: Научно-медицинская фирма «МБН», 2002. 163 с.
- Регистр лекарственных средств России «Энциклопедия лекарств». М.: 000 «РЛС-2004», С. 675-676.
- Шкала тревоги. Тест на тревожность Спилбергера Ханина. Электронный ресурс: http://psycabi.net/testy/179-test-na-trevozhnost-spilbergera-khanina-metodika-otsenki-trevozhnosti-ch-d-spilbergera-i-yu-l-khanina
- Bormann J. The «ABC» of GABA receptors // Trends Pharmacol Sci. 2000. Vol. 21. P. 16-19.
- Bohlhalter S., Goldfine A., Matteson S. et al. Neural correlates of tic generation in Tourette syndrome: an event-related functional MRI study // Brain. 2006. Vol. 129 (8). P. 2029-2037.
- Du J.C., Chiu T.F., Lee K.M. et al. Tourette syndrome in children: an updated review // Pediatr. Neonatol. 2010. Vol. 51 (5). P. 255-264.
- Hong K.E., Ock S.M., Kang M.H. et al. The segmented regional volumes of the cerebrum and cerebellum in boys with Tourette syndrome // J. Korean Med. Sci. 2002. Vol. 17 (4). P. 530-536.
- Jankovic J. Tourette’s syndrome // N. Engl. J. Med. 2001. Vol. 345. P. 1184-1192.
- Korpi E.R., Grunder G., Luddens H. Drug interactions at GABAA receptors // Prog Neurobiol. 2002 Vol. 67. P. 113-159.
- Kurlan R. Clinical practice. Tourette’s Syndrome // N. Engl. J. Med. 2010. Vol. 363 (24). P. 2332-2338.
- Leckman J.F., Riddle M.A., Hardin M.T. et al. The Yale Global Tic Severity Scale; initial testing of a clinical - rated scale of tic severity // J. Am Acad Child Adolesc Psychiatry. 1989. Vol.28. P.566-573.
