Email this article ANALYSIS OF GENE POLYMORPHISM, DETERMINING CARRIAGE OF HYPERHOMOCYSTEINEMIA IN RECURRENT ISCHEMIC STROKE IN YOUNG AND MIDDLE-AGED PATIENTS
- Authors: Skorokhodov A.P1, Dutova T.I1
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Affiliations:
- 394036, Voronezh, Studencheskaya street, 10
- Issue: Vol XLV, No 1 (2013)
- Pages: 40-44
- Section: Articles
- URL: https://journals.rcsi.science/1027-4898/article/view/13780
- DOI: https://doi.org/10.17816/nb13780
- ID: 13780
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Abstract
The analysis of gene polymorphism determining carrier hyperhomocysteinemia at recurrent ischemic stroke in young and middle-aged has been performed. It was shown that the level of homocysteine in recurrent ischemic stroke is higher than in single, and the level of vitamin B12 at repeated strokes is lower than at the individual ones, and level of folic acid is decreased both at the repeated insults, and at individual. The risk of ischemic stroke increases not only in the case of a combination of several mutations in the patient, leading to hyperhomocysteinemia, but also in any other combination of factors - both genetic and exogenous. The leading role in the development of hyperhomocysteinemia at ischemic stroke in young and middle age has (GE10), gene of methionine synthase reductase MTRR.
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##article.viewOnOriginalSite##About the authors
Alexander P Skorokhodov
394036, Voronezh, Studencheskaya street, 10394036, Воронеж, Студенческая, 10
Tatiana I Dutova
394036, Voronezh, Studencheskaya street, 10
Email: dutova80@mail.ru
394036, Воронеж, Студенческая, 10
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