NEUROPROTECTIVE EFFECT OF ENDACANNABINOID N-ARACHIDONOYLDOPAMINE IN ACUTE HYPOBARIC HYPOXIA


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Abstract

The effect of the endogenous cannabinoid N-arachi-donoyldopamin (AA-DA) in acute hypobaric hypoxia in mice was studied. The lifetime of the animals at the height, survival, changes in locomotor activity with the test «open field» and the long-term memory with test «Morris water maze» were evaluated. It was revealed that injection of AA-DA significantly increased survival animals and long-term memory in remote period of acute hypoxia. Neuroprotective effect of AA-DA was shown.

About the authors

Elena V Mitroshina

1) Nizhny Novgorod State Medical Academy, 2)The N.I. Lobachevsky Nizhny Novgorod State University

Email: mitroshinae@list.ru
1) Nizhny Novgorod State Medical Academy, 2)The N.I. Lobachevsky Nizhny Novgorod State University

Maria V Vedunova

1) Nizhny Novgorod State Medical Academy; 2)The N.I. Lobachevsky Nizhny Novgorod State University

1) Nizhny Novgorod State Medical Academy; 2)The N.I. Lobachevsky Nizhny Novgorod State University

Andrei A Mironov

1) Nizhny Novgorod State Medical Academy; 2)The N.I. Lobachevsky Nizhny Novgorod State University

1) Nizhny Novgorod State Medical Academy; 2)The N.I. Lobachevsky Nizhny Novgorod State University

Tatyana A Saharnova

1) Nizhny Novgorod State Medical Academy, 2)The N.I. Lobachevsky Nizhny Novgorod State University

1) Nizhny Novgorod State Medical Academy, 2)The N.I. Lobachevsky Nizhny Novgorod State University

Alexei S Pimashkin

The N.I. Lobachevsky Nizhny Novgorod State University

The N.I. Lobachevsky Nizhny Novgorod State University

Mikhail Y Bobrov

1) Institute of biochemistry, named after academicians М.М. Shemyakin and Yu. A. Оvchinnikov, RAS; 2) State Institution Scientific Neurology centre of RAMS

1) Institute of biochemistry, named after academicians М.М. Shemyakin and Yu. A. Оvchinnikov, RAS; 2) State Institution Scientific Neurology centre of RAMS

Leonid G Khaspeckov

State Institution Scientific Neurology centre of RAMS

State Institution Scientific Neurology centre of RAMS

Irina V Mukhin

1) Nizhny Novgorod State Medical Academy; 2)The N.I. Lobachevsky Nizhny Novgorod State University

1) Nizhny Novgorod State Medical Academy; 2)The N.I. Lobachevsky Nizhny Novgorod State University

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Copyright (c) 2012 Mitroshina E.V., Vedunova M.V., Mironov A.A., Saharnova T.A., Pimashkin A.S., Bobrov M.Y., Khaspeckov L.G., Mukhin I.V.

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