ENDOTHELIUM DYSFUNCTION AND STATE OF STRUCTURAL-FUNCTIONAL LEVELS OF CEREBRAL VASCULAR SYSTEM AT HYPERTENSIVE ENCEPHALOPATHY

With the purpose of detection an endothelium dysfunction role in the hypertensive encephalopathy (HE) progressing, 209 HE I-HE III patients were examined. The HE pathogenetic subtypes were detected: the ones with constitutional phlebopathy (CPP) and HE pathogenetic subtypes without it (NP). A cliniconeurologic investigation, diurnal arterial blood pressure monitoring was held, with ultrasonic imaging an endothelium function and cerebral haemodynamics research was carried out. It was established, that the endothelium function is disordered in the initial disease stage to an equal degree under various HE subtypes, the rates of diurnal index and arterial blood pressure rising speed in HE patients differ from control rates. The endothelium function in all patient groups is influenced by smoking; by arterial blood pressure variability in CPP group; also by age and arterial blood pressure load in NP patients. Pathologic active conditions, progressing on all the cerebral vascular system structural-functional levels under HE, were analyzed; an endothelium function participation in the pathologic active conditions progressing was shown.

hypertensive encephalopathy, constitutional phlebopathy, endothelium dysfunction, cerebral haemodynamics