R. von den Velden. Observations on epileptics. The value of sodium chloride in some forms of epilepsy. Ein Beitrag zur Bedeutung des Chlornatrium fur gemisse Formen der Epilepsie—Deutsehe Zeitschrift für Nervenheilkunde, Bd. 38, 1909

At the beginning of the article, the author dwells on a whole series of studies on the displacement of chlorides in the body by bromides, studies that led to the recognition of the specific, toxic effect of bromine on nerve elements. By directly stimulating the gray matter of the brain of trepanned animals, Rosentach confirmed these observations with experimental data. But animal experiments published by Wyss in 1908 suggest that the effect of bromine therapy does not depend on the medicinal properties of bromine itself, but on the fact that bromine salts displace from the body part of the sodium chloride, which is harmful to epileptics.