Effect of some metabiotics from strains of the genus Enterococcus on the growth of pathogenic bacteria that cause pneumonia

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It is shown that the highest antimicrobial activity (100%) against strains of Kl. pneumonia and St. pneumonia of strains causing pneumonia occurs when using protein-like fractions (AMP) obtained from CL after cultivation of LAB of strains of the genus Enterococcus isolated from fermented milk of goats and donkeys, and the lowest activity of AMP from CL of strains isolated from fermented milk of cows (20–50%). It was shown that the isolated polysaccharides of strains of the genus Enterococcus, which have antimicrobial activity, consist of glucose and galactose molecules. The difference in the effectiveness of the influence of polysaccharides depends on the source of the isolated pathogens, depends on the concentration of the polysaccharide, the genus and species of the strain causing pneumonia. It is concluded that some metabiotics of the Enterococcus genus are promising for use as bioinhibitors of the growth of pathogenic bacteria.

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А. Israyelyan

Artsakh Scientific Center State Non-Commercial Organization

编辑信件的主要联系方式.
Email: arevik_israelyan@mail.ru
阿塞拜疆, Tigran Mets 26, Stepanakert, 2600

Ts. Balabekyan

Scientific and Production Center Armbiotechnology NSPO, National Academy of Science

Email: arevik_israelyan@mail.ru
亚美尼亚, Gyurjyan 14, Yerevan, 0056

Z. Sargsyan

Center for Epidemiology and Hygiene

Email: arevik_israelyan@mail.ru
阿塞拜疆, Ar. Arakelyan 14, Stepanakert, 2600

F. Tkhruni

Scientific and Production Center Armbiotechnology NSPO, National Academy of Science

Email: arevik_israelyan@mail.ru
亚美尼亚, Gyurjyan 14, Yerevan, 0056

参考

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  5. Israyelyan A., Karapetyan K., Tkhruni F., Arstamyan L., Balabekyan T. Sensitivity of different pathogens to biological antimicrobial agents // European Journal of Biomedical and Life Sciences. 2015. V. 3. P. 61–66.
  6. Israyelyan A.L., Tkhruni F.N., Arstamyan L.A., Balabekyan T.R., Khachatryan T.V., Karapetyan K.J. Comparative characterization of endemic lactic acid bacteria isolated from several regions of Armenia and Nagorno Karabakh Republics // Biolog. Journ. of Armenia, NAS RA. 2016. P. 50–57.
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  9. Karapetyan K., Tkhruni F., Israyelyan A., Yermolenko E., Verdyan A. Comparative characterization of endemic lactic acid bacteria of Enterococcus genus // International Science of technology. 2017. V. 6. P. 357–365.
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2. Fig. 1. Antimicrobial activity of protein-containing fractions obtained after purification of the supernatant of the KZh strain Ent. faecium KE-5 by gel filtration against St. pneumonia

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3. Fig. 2. Effect of antimicrobial drugs against strains isolated from infected eyes, ∅ mm

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4. Fig. 3. Effect of antibiotics on strains isolated from infected eyes, ∅ mm

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5. Fig. 4. Effect of antimicrobial drugs on the growth of bacteria isolated from the pharynx, ∅ mm

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6. Fig. 5. Effect of antibiotics on the growth of isolated bacteria from the throat, ∅ mm

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7. Fig. 6. Antimicrobial activity of BCN 2 (bacteriocin) against some human pathogenic bacteria

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