The effect of dalargin on the level of corticosterone in rats with different individual typological features of behavior in the PTSD model
- Authors: Semenova O.G.1, Vyushina A.V.1, Pritvorova A.V.1, Pivina S.G.1, Ordyan N.E.1
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Affiliations:
- I. P. Pavlov Institute of Physiology, Russian Academy of Sciences
- Issue: No 2 (2024)
- Pages: 216-222
- Section: ANIMAL AND HUMAN PHYSIOLOGY
- URL: https://journals.rcsi.science/1026-3470/article/view/261359
- DOI: https://doi.org/10.31857/S1026347024020059
- EDN: https://elibrary.ru/WCCUCY
- ID: 261359
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Abstract
The effect of the synthetic analogue of leu-enkephalin (dalargin) on the level of corticosterone in the blood and the mass of the adrenal glands in rats with various typological features of behavior in the model of post-traumatic stress disorder (PTSD) was studied. Groups were formed: active low-anxiety (ALA) and high-anxiety (AHA), as well as passive low-anxiety (PLA) and high-anxiety (PHA) rats. Each of the 4 groups of rats was divided into 3 subgroups, where subgroup 1 is an intact control. 20 days after the first stressful exposure, rats from subgroup 3 were injected intramuscularly with the dalargin for 7 days, and rats from subgroup 2 were injected with the saline solution. It was found that the course of injections of dalargin into rats in the PTSD model had a positive effect on the studied indicators only in the group of active highly-anxiety animals.
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About the authors
O. G. Semenova
I. P. Pavlov Institute of Physiology, Russian Academy of Sciences
Author for correspondence.
Email: Pritvorovaav@infran.ru
Russian Federation, 199034, St. Petersburg, Makarova emb., 6
A. V. Vyushina
I. P. Pavlov Institute of Physiology, Russian Academy of Sciences
Email: Pritvorovaav@infran.ru
Russian Federation, 199034, St. Petersburg, Makarova emb., 6
A. V. Pritvorova
I. P. Pavlov Institute of Physiology, Russian Academy of Sciences
Email: Pritvorovaav@infran.ru
Russian Federation, 199034, St. Petersburg, Makarova emb., 6
S. G. Pivina
I. P. Pavlov Institute of Physiology, Russian Academy of Sciences
Email: Pritvorovaav@infran.ru
Russian Federation, 199034, St. Petersburg, Makarova emb., 6
N. E. Ordyan
I. P. Pavlov Institute of Physiology, Russian Academy of Sciences
Email: Pritvorovaav@infran.ru
Russian Federation, 199034, St. Petersburg, Makarova emb., 6
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