Fundamentally low reproducibility in molecular genetic cancer research


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The review discusses the causes of multiple failures in cancer treatment, which might primarily result from the excessive variability of cancer genomes. They are capable of changing their spatial and temporal architecture during tumor development. The key reasons of irreproducibility of biomedical data and the presumable means for improvement of therapeutic results aiming at targeting the most stable tumor traits are suggested.

作者简介

I. Alekseenko

Shemyakin–Ovchinnikov Institute of Bioorganic Chemistry

编辑信件的主要联系方式.
Email: irina.alekseenko@mail.ru
俄罗斯联邦, Moscow, 117997

V. Pleshkan

Shemyakin–Ovchinnikov Institute of Bioorganic Chemistry

Email: irina.alekseenko@mail.ru
俄罗斯联邦, Moscow, 117997

G. Monastyrskaya

Shemyakin–Ovchinnikov Institute of Bioorganic Chemistry

Email: irina.alekseenko@mail.ru
俄罗斯联邦, Moscow, 117997

A. Kuzmich

Shemyakin–Ovchinnikov Institute of Bioorganic Chemistry

Email: irina.alekseenko@mail.ru
俄罗斯联邦, Moscow, 117997

E. Snezhkov

Shemyakin–Ovchinnikov Institute of Bioorganic Chemistry

Email: irina.alekseenko@mail.ru
俄罗斯联邦, Moscow, 117997

D. Didych

Shemyakin–Ovchinnikov Institute of Bioorganic Chemistry

Email: irina.alekseenko@mail.ru
俄罗斯联邦, Moscow, 117997

E. Sverdlov

Shemyakin–Ovchinnikov Institute of Bioorganic Chemistry

Email: irina.alekseenko@mail.ru
俄罗斯联邦, Moscow, 117997

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