Fundamentally low reproducibility in molecular genetic cancer research
- Авторы: Alekseenko I.V.1, Pleshkan V.V.1, Monastyrskaya G.S.1, Kuzmich A.I.1, Snezhkov E.V.1, Didych D.A.1, Sverdlov E.D.1
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Учреждения:
- Shemyakin–Ovchinnikov Institute of Bioorganic Chemistry
- Выпуск: Том 52, № 7 (2016)
- Страницы: 650-663
- Раздел: Article
- URL: https://journals.rcsi.science/1022-7954/article/view/187774
- DOI: https://doi.org/10.1134/S1022795416070036
- ID: 187774
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Аннотация
The review discusses the causes of multiple failures in cancer treatment, which might primarily result from the excessive variability of cancer genomes. They are capable of changing their spatial and temporal architecture during tumor development. The key reasons of irreproducibility of biomedical data and the presumable means for improvement of therapeutic results aiming at targeting the most stable tumor traits are suggested.
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Об авторах
I. Alekseenko
Shemyakin–Ovchinnikov Institute of Bioorganic Chemistry
Автор, ответственный за переписку.
Email: irina.alekseenko@mail.ru
Россия, Moscow, 117997
V. Pleshkan
Shemyakin–Ovchinnikov Institute of Bioorganic Chemistry
Email: irina.alekseenko@mail.ru
Россия, Moscow, 117997
G. Monastyrskaya
Shemyakin–Ovchinnikov Institute of Bioorganic Chemistry
Email: irina.alekseenko@mail.ru
Россия, Moscow, 117997
A. Kuzmich
Shemyakin–Ovchinnikov Institute of Bioorganic Chemistry
Email: irina.alekseenko@mail.ru
Россия, Moscow, 117997
E. Snezhkov
Shemyakin–Ovchinnikov Institute of Bioorganic Chemistry
Email: irina.alekseenko@mail.ru
Россия, Moscow, 117997
D. Didych
Shemyakin–Ovchinnikov Institute of Bioorganic Chemistry
Email: irina.alekseenko@mail.ru
Россия, Moscow, 117997
E. Sverdlov
Shemyakin–Ovchinnikov Institute of Bioorganic Chemistry
Email: irina.alekseenko@mail.ru
Россия, Moscow, 117997
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