Polymorphism of CD209 and TLR3 genes in populations of North Eurasia
- Autores: Barkhash A.1, Babenko V.1, Voevoda M.1,2,3, Romaschenko A.1
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Afiliações:
- Institute of Cytology and Genetics, Siberian Branch
- Institute of Internal and Preventive Medicine
- Novosibirsk State University
- Edição: Volume 52, Nº 6 (2016)
- Páginas: 608-614
- Seção: Human Genetics
- URL: https://journals.rcsi.science/1022-7954/article/view/187754
- DOI: https://doi.org/10.1134/S1022795416040025
- ID: 187754
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Resumo
The DC-SIGN (dendritic cell-specific intercellular adhesion molecule (ICAM)-3-grabbing non-integrin) and TLR3 (toll-like receptor 3) proteins are key effectors of the innate immunity and particularly play an important role in the organism’s antiviral defense as pattern-recognition receptors. Previously, we demonstrated that certain genotypes and alleles of single nucleotide polymorphisms (SNPs) rs2287886 (G/A) in the promoter region of the CD209 gene (encoding DC-SIGN) and rs3775291 (G/A, Leu412Phe) in the exon 4 of the TLR3 gene are associated with human predisposition to tick-borne encephalitis in the Russian population. In the present work, the distribution of genotype and allele frequencies for these SNPs was studied in seven populations of North Eurasia, including Caucasians (Russians and Germans (from Altai region)), Central Asian Mongoloids (Altaians, Khakass, Tuvinians, and Shorians), and Arctic Mongoloids (Chukchi). It was found that the CD209 gene rs2287886 SNP A/A genotype and A allele, as well as the TLR3 gene rs3775291 SNP G/G genotype and G allele (the frequencies of which in our previous studies were increased in tick-borne encephalitis patients as compared with the population control (Russian citizens of Novosibirsk)), are preserved with a high frequency in Central Asian Mongoloids (who for a long time regularly came in contact with tick-borne encephalitis virus in places of their habitation). We suggested that predisposition to tick-borne encephalitis in Central Asian Mongoloid populations can be predetermined by a different set of genes and their polymorphisms than in the Russian population.
Sobre autores
A. Barkhash
Institute of Cytology and Genetics, Siberian Branch
Autor responsável pela correspondência
Email: barkhash@bionet.nsc.ru
Rússia, Novosibirsk, 630090
V. Babenko
Institute of Cytology and Genetics, Siberian Branch
Email: barkhash@bionet.nsc.ru
Rússia, Novosibirsk, 630090
M. Voevoda
Institute of Cytology and Genetics, Siberian Branch; Institute of Internal and Preventive Medicine; Novosibirsk State University
Email: barkhash@bionet.nsc.ru
Rússia, Novosibirsk, 630090; Novosibirsk, 630089; Novosibirsk, 630090
A. Romaschenko
Institute of Cytology and Genetics, Siberian Branch
Email: barkhash@bionet.nsc.ru
Rússia, Novosibirsk, 630090