Gene therapy of arthritis
- Autores: Nepomnyashchikh T.1, Antonets D.1, Shchelkunov S.1
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Afiliações:
- State Research Center of Virusology and Biotechnology “Vector”
- Edição: Volume 52, Nº 6 (2016)
- Páginas: 543-556
- Seção: Reviews and Theoretical Articles
- URL: https://journals.rcsi.science/1022-7954/article/view/187733
- DOI: https://doi.org/10.1134/S1022795416050094
- ID: 187733
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Resumo
Gene therapy can offer a new approach to arthritis treatment which acts at an inflammation site. Numerous studies show high efficacy of gene therapy in different models of arthritis in humans. Even a single injection of a recombinant vector results in a stable prolonged expression of a therapeutic gene and a longterm therapeutic effect. In contrast to biologic therapy involving numerous systemic injections of recombinant anti-inflammatory proteins, gene therapy does not produce systemic side effects. Vectors based on retroviruses, adenoviruses, adeno-associated viruses, and recombinant plasmids could provide delivery of target genes. Of significant importance is the development of noninvasive methods of gene therapy: intranasal and peroral. The current state of research in arthritis gene therapy is discussed in this review.
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Sobre autores
T. Nepomnyashchikh
State Research Center of Virusology and Biotechnology “Vector”
Email: snshchel@vector.nsc.ru
Rússia, Novosibirsk, Koltsovo, 630559
D. Antonets
State Research Center of Virusology and Biotechnology “Vector”
Email: snshchel@vector.nsc.ru
Rússia, Novosibirsk, Koltsovo, 630559
S. Shchelkunov
State Research Center of Virusology and Biotechnology “Vector”
Autor responsável pela correspondência
Email: snshchel@vector.nsc.ru
Rússia, Novosibirsk, Koltsovo, 630559