Email this article Development of Multiplex Genotyping Method of Polymorphic Markers of Genes Associated with Cognitive Abilities
- Authors: Vagaitseva K.V.1,2, Bocharova A.V.1, Marusin A.V.1, Kolesnikova E.A.2, Makeeva O.A.1,3, Stepanov V.A.1,2
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Affiliations:
- Research Institute of Medical Genetics
- National Research Tomsk State University
- Center for Clinical Trials
- Issue: Vol 54, No 6 (2018)
- Pages: 740-745
- Section: Methods
- URL: https://journals.rcsi.science/1022-7954/article/view/189036
- DOI: https://doi.org/10.1134/S1022795418060121
- ID: 189036
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Abstract
A developed method of multiplex genotyping of polymorphic markers of genes associated with cognitive abilities and neuropsychiatric diseases is based on multilocus PCR and MALDI-TOF mass spectrometry of DNA molecules. The frequencies of 32 single-nucleotide markers localized in 24 genes are analyzed in a sample of elderly people from the Russian population of Tomsk. The data obtained are compared with data for populations from the 1000 Genomes Project.
About the authors
K. V. Vagaitseva
Research Institute of Medical Genetics; National Research Tomsk State University
Author for correspondence.
Email: kseniya.simonova@medgenetics.ru
Russian Federation, Tomsk, 634050; Tomsk, 634050
A. V. Bocharova
Research Institute of Medical Genetics
Email: kseniya.simonova@medgenetics.ru
Russian Federation, Tomsk, 634050
A. V. Marusin
Research Institute of Medical Genetics
Email: kseniya.simonova@medgenetics.ru
Russian Federation, Tomsk, 634050
E. A. Kolesnikova
National Research Tomsk State University
Email: kseniya.simonova@medgenetics.ru
Russian Federation, Tomsk, 634050
O. A. Makeeva
Research Institute of Medical Genetics; Center for Clinical Trials
Email: kseniya.simonova@medgenetics.ru
Russian Federation, Tomsk, 634050; Tomsk, 634009
V. A. Stepanov
Research Institute of Medical Genetics; National Research Tomsk State University
Email: kseniya.simonova@medgenetics.ru
Russian Federation, Tomsk, 634050; Tomsk, 634050
