Insulators can disrupt weak transcription derived from the white gene enhancer in Drosophila transgenic lines
- 作者: Kyrchanova O.V.1, Postika N.Y.1, Parshikov A.F.1, Georgiev P.G.1
-
隶属关系:
- Institute of Gene Biology
- 期: 卷 52, 编号 11 (2016)
- 页面: 1204-1207
- 栏目: Short Communications
- URL: https://journals.rcsi.science/1022-7954/article/view/188003
- DOI: https://doi.org/10.1134/S1022795416110089
- ID: 188003
如何引用文章
详细
Increasing evidence suggests that noncoding RNA transcribed from the enhancers play an important role in the regulation of gene transcription. Insulators are the regulatory elements that limit the activity of enhancers and form independent transcriptional domains. Using a transgenic lines, we show that the Fab-7 insulator of the bithorax complex and the MDG4 (gypsy) insulator are able to disrupt weak transcription derived from the enhancer regulating the white gene expression in the eyes. The ability of insulators to disrupt weak transcription may play a role in the enhancer-blocking activity.
关键词
作者简介
O. Kyrchanova
Institute of Gene Biology
编辑信件的主要联系方式.
Email: olgina73@gmail.com
俄罗斯联邦, Moscow, 119334
N. Postika
Institute of Gene Biology
Email: olgina73@gmail.com
俄罗斯联邦, Moscow, 119334
A. Parshikov
Institute of Gene Biology
Email: olgina73@gmail.com
俄罗斯联邦, Moscow, 119334
P. Georgiev
Institute of Gene Biology
Email: olgina73@gmail.com
俄罗斯联邦, Moscow, 119334
补充文件
