Genetic characterization of Balkars and Karachays according to the variability of the Y chromosome
- Authors: Dzhaubermezov M.A.1, Ekomasova N.V.1, Litvinov S.S.2,3, Khusainova R.I.1,2, Akhmetova V.L.2, Balinova N.V.4, Khusnutdinova E.K.1,2
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Affiliations:
- Department of Genetics and Fundamental Medicine
- Institute of Biochemistry and Genetics, Ufa Scientific Center
- Department of Evolutionary Biology, Institute of Molecular and Cell Biology
- Research Centre for Medical Genetics
- Issue: Vol 53, No 10 (2017)
- Pages: 1152-1158
- Section: Human Genetics
- URL: https://journals.rcsi.science/1022-7954/article/view/188494
- DOI: https://doi.org/10.1134/S1022795417100039
- ID: 188494
Cite item
Abstract
The genetic diversity in two ethnic groups of the central part of the North Caucasus (Balkars and Karachays) using 50 diallelic loci in the non-recombining region of the Y chromosome was analyzed. For the first time, an analysis of distribution of frequencies of Y-chromosome haplogroups in Balkars considering different subethnic groups (Baksans, Chegems, Kholams, Bezengiyevs, and Malkars) was conducted. The major Y-chromosome haplogroups in the studied groups of Balkars and Karachays were G2a-P16 and R1a- Z2123. In addition, for a better understanding of genetic relationship between the male lineages in the studied populations and other populations of the Caucasus, we performed an analysis of R1a-M198 subhaplogroups in 22 populations of this region. The principal component analysis demonstrated that a greater difference was observed between Kholams and the other Balkar subgroups. According to the Fst analysis, Chegems, for which the prevalence of haplogroup R1b-M478 (32.2%) was reported, demonstrated the maximum difference from the other subpopulations of Balkars and Karachays.
Keywords
About the authors
M. A. Dzhaubermezov
Department of Genetics and Fundamental Medicine
Author for correspondence.
Email: murat-kbr@mail.ru
Russian Federation, Ufa, 450074
N. V. Ekomasova
Department of Genetics and Fundamental Medicine
Email: murat-kbr@mail.ru
Russian Federation, Ufa, 450074
S. S. Litvinov
Institute of Biochemistry and Genetics, Ufa Scientific Center; Department of Evolutionary Biology, Institute of Molecular and Cell Biology
Email: murat-kbr@mail.ru
Russian Federation, Ufa, 450054; Tartu, 51010
R. I. Khusainova
Department of Genetics and Fundamental Medicine; Institute of Biochemistry and Genetics, Ufa Scientific Center
Email: murat-kbr@mail.ru
Russian Federation, Ufa, 450074; Ufa, 450054
V. L. Akhmetova
Institute of Biochemistry and Genetics, Ufa Scientific Center
Email: murat-kbr@mail.ru
Russian Federation, Ufa, 450054
N. V. Balinova
Research Centre for Medical Genetics
Email: murat-kbr@mail.ru
Russian Federation, Moscow, 115478
E. K. Khusnutdinova
Department of Genetics and Fundamental Medicine; Institute of Biochemistry and Genetics, Ufa Scientific Center
Email: murat-kbr@mail.ru
Russian Federation, Ufa, 450074; Ufa, 450054