Search for osteoarthritis genetic markers in women with undifferentiated connective tissue dysplasia


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Resumo

We conducted an association study of ten polymorphisms in six candidate genes of OA (rs1799750 (MMP1), rs35068180 (MMP3), rs2252070 (MMP13), rs63118460 and rs2276455 (COL2A1), rs143383 (GDF5), rs1544410, rs7975232, rs731236, and rs2228570 (VDR)) with the development of osteoarthritis (OA) in 333 women taking into account the localization of the pathological process, the age of disease manifestation, and ethnicity and investigated the presence of signs of undifferentiated connective tissue dysplasia (UCTD). On the basis of clinical and genetic data, we revealed statistically significant models to predict the development of osteoarthritis of various localizations (knee, hip, and generalized forms).

Sobre autores

R. Khusainova

Institute of Biochemistry and Genetics, Ufa Scientific Center

Autor responsável pela correspondência
Email: ritakh@mail.ru
Rússia, Ufa, 450054

A. Tyurin

Department of Hospital Therapy No. 2

Email: ritakh@mail.ru
Rússia, Ufa, 450076

D. Shapovalova

Institute of Biochemistry and Genetics, Ufa Scientific Center

Email: ritakh@mail.ru
Rússia, Ufa, 450054

E. Khusnutdinova

Institute of Biochemistry and Genetics, Ufa Scientific Center

Email: ritakh@mail.ru
Rússia, Ufa, 450054

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