Отправить статью по E-mail Search for osteoarthritis genetic markers in women with undifferentiated connective tissue dysplasia
- Авторы: Khusainova R.I.1, Tyurin A.V.2, Shapovalova D.A.1, Khusnutdinova E.K.1
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Учреждения:
- Institute of Biochemistry and Genetics, Ufa Scientific Center
- Department of Hospital Therapy No. 2
- Выпуск: Том 53, № 7 (2017)
- Страницы: 785-794
- Раздел: Human Genetics
- URL: https://journals.rcsi.science/1022-7954/article/view/188341
- DOI: https://doi.org/10.1134/S1022795417060072
- ID: 188341
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Аннотация
We conducted an association study of ten polymorphisms in six candidate genes of OA (rs1799750 (MMP1), rs35068180 (MMP3), rs2252070 (MMP13), rs63118460 and rs2276455 (COL2A1), rs143383 (GDF5), rs1544410, rs7975232, rs731236, and rs2228570 (VDR)) with the development of osteoarthritis (OA) in 333 women taking into account the localization of the pathological process, the age of disease manifestation, and ethnicity and investigated the presence of signs of undifferentiated connective tissue dysplasia (UCTD). On the basis of clinical and genetic data, we revealed statistically significant models to predict the development of osteoarthritis of various localizations (knee, hip, and generalized forms).
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R. Khusainova
Institute of Biochemistry and Genetics, Ufa Scientific Center
Автор, ответственный за переписку.
Email: ritakh@mail.ru
Россия, Ufa, 450054
A. Tyurin
Department of Hospital Therapy No. 2
Email: ritakh@mail.ru
Россия, Ufa, 450076
D. Shapovalova
Institute of Biochemistry and Genetics, Ufa Scientific Center
Email: ritakh@mail.ru
Россия, Ufa, 450054
E. Khusnutdinova
Institute of Biochemistry and Genetics, Ufa Scientific Center
Email: ritakh@mail.ru
Россия, Ufa, 450054
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