Gene dilp6 regulates octopamine metabolism in Drosophila melanogaster


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The effect of strong hypomorphic mutation of the insulin-like protein gene (dilp6) on metabolism of octopamine (one of the main biogenic amines in insects) was studied in Drosophila melanogaster males and females. The activity of tyrosine decarboxylase (the key enzyme of octopamine synthesis) and the activity of octopamine-dependent N-acetyltransferase (the enzyme of its degradation) were measured. It was demonstrated that the activity of both studied enzymes is decreased under normal conditions in the dilp641 mutants (as we previously demonstrated, this is correlated with an increased level of octopamine). It was also found that hypomorphic mutation of the dilp6 gene decreases the intensity of tyrosine decarboxylase response to heat stress. Thus, it was demonstrated for the first time that insulin-like DILP6 protein in drosophila influences the level of octopamine (regulating the activity of the enzyme degrading octopamine).

作者简介

E. Burdina

Federal Research Center Institute of Cytology and Genetics, Siberian Branch

Email: iraushen@bionet.nsc.ru
俄罗斯联邦, Novosibirsk, 630090

N. Adonyeva

Federal Research Center Institute of Cytology and Genetics, Siberian Branch

Email: iraushen@bionet.nsc.ru
俄罗斯联邦, Novosibirsk, 630090

N. Gruntenko

Federal Research Center Institute of Cytology and Genetics, Siberian Branch

Email: iraushen@bionet.nsc.ru
俄罗斯联邦, Novosibirsk, 630090

I. Rauschenbach

Federal Research Center Institute of Cytology and Genetics, Siberian Branch

编辑信件的主要联系方式.
Email: iraushen@bionet.nsc.ru
俄罗斯联邦, Novosibirsk, 630090

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