Optogenetics and Vision
- Authors: Kirpichnikov M.P.1,2, Ostrovsky M.A.2,3
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Affiliations:
- Shemyakin–Ovchinnikov Institute of Bioorganic Chemistry, Russian Academy of Sciences
- Moscow State University
- Emanuel Institute of Biochemical Physics, Russian Academy of Sciences
- Issue: Vol 89, No 1 (2019)
- Pages: 34-38
- Section: Review
- URL: https://journals.rcsi.science/1019-3316/article/view/179496
- DOI: https://doi.org/10.1134/S1019331619010039
- ID: 179496
Cite item
Abstract
The authors discuss the main strategies for returning vision to blind people: electronic and optogenetic prosthetics of degenerative (blind) retina. Primary attention is paid to the prospects of retinal prosthetics for the blind using the methods of modern optogenetics. Photosensitive retinal-containing proteins, rhodopsins, are considered as tools for such prosthetics. The question of which particular cells of the degenerative retina and which rhodopsins can be prosthetic, as well as the ways of delivering the rhodopsin genes to these cells, is discussed. In conclusion, the main provisions and problems related to optogenetic prosthetics of degenerative retina are formulated.
About the authors
M. P. Kirpichnikov
Shemyakin–Ovchinnikov Institute of Bioorganic Chemistry, Russian Academy of Sciences; Moscow State University
Author for correspondence.
Email: kirpichnikov@inbox.ru
Russian Federation, Moscow, 117997; Moscow, 119991
M. A. Ostrovsky
Moscow State University; Emanuel Institute of Biochemical Physics, Russian Academy of Sciences
Author for correspondence.
Email: ostrovsky3535@mail.ru
Russian Federation, Moscow, 119991; Moscow, 119991