Мақаланы E-mail арқылы жіберу Quantitative Susceptibility Mapping of the Substantia Nigra in Parkinson’s Disease
- Авторлар: Zhao X.1, An H.2, Liu T.3, Shen N.2, Bo B.1, Zhang Z.1, Weng P.1, Chen M.1, Pei M.1, Wang Y.1,3, Huang D.2, Li J.1
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Мекемелер:
- Shanghai Key Laboratory of Magnetic Resonance, Department of Physics, East China Normal University
- Department of Neurology, School of Medicine, East Hospital Affiliated to Tongji University
- Department of Radiology, Weill Medical College of Cornell University
- Шығарылым: Том 48, № 6 (2017)
- Беттер: 533-544
- Бөлім: Original Paper
- URL: https://journals.rcsi.science/0937-9347/article/view/247697
- DOI: https://doi.org/10.1007/s00723-017-0877-x
- ID: 247697
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Рұқсат берілді
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Аннотация
The purpose of this study was to evaluate the sensitivities of quantitative susceptibility mapping (QSM) and R2* mapping in clinical diagnoses of Parkinson’s disease (PD). QSM images and R2* maps from 29 patients with PD and 25 healthy controls were obtained on a clinical 3T magnetic resonance imaging (MRI) system using a three-dimensional multi-echo gradient-echo sequence. Two-tailed t tests and receiver operating characteristic curves analyses were applied to the mean values of QSM and R2* of the two groups. In the PD group, a two-tailed Pearson correlation analysis was used to investigate the correlations between MRI measures (susceptibility and R2* values) and the Unified Parkinson’s Disease Rating Scale-III (UPDRS-III) score. In the substantia nigra (SN), a significant difference between patients with PD and healthy controls was found on QSM (154.80 ± 43.36 vs. 127.50 ± 21.05 ppb, P = 0.006) but not on R2* mapping. The receiver operating characteristic curves showed that QSM was more sensitive than R2* mapping to distinguish PD patients from healthy controls, with areas under the curve equal to 0.68 and 0.51, respectively. The UPDRS-III motor scores did not correlate with mean susceptibility or R2* values in the PD group. In conclusion, QSM is a more accurate and sensitive method than R2* mapping to detect the pathologic changes in the SN of patients with PD.
Авторлар туралы
Xinxin Zhao
Shanghai Key Laboratory of Magnetic Resonance, Department of Physics, East China Normal University
Email: jqli@phy.ecnu.edu.cn
ҚХР, 3663 North Zhongshan Road, Shanghai, 200062
Hedi An
Department of Neurology, School of Medicine, East Hospital Affiliated to Tongji University
Email: jqli@phy.ecnu.edu.cn
ҚХР, 150 Jimo Road, Pudong, Shanghai, 200120
Tian Liu
Department of Radiology, Weill Medical College of Cornell University
Email: jqli@phy.ecnu.edu.cn
АҚШ, 515 East 71st St., Suite S106, New York, NY, 10021
Nan Shen
Department of Neurology, School of Medicine, East Hospital Affiliated to Tongji University
Email: jqli@phy.ecnu.edu.cn
ҚХР, 150 Jimo Road, Pudong, Shanghai, 200120
Binshi Bo
Shanghai Key Laboratory of Magnetic Resonance, Department of Physics, East China Normal University
Email: jqli@phy.ecnu.edu.cn
ҚХР, 3663 North Zhongshan Road, Shanghai, 200062
Zhuwei Zhang
Shanghai Key Laboratory of Magnetic Resonance, Department of Physics, East China Normal University
Email: jqli@phy.ecnu.edu.cn
ҚХР, 3663 North Zhongshan Road, Shanghai, 200062
Pengfei Weng
Shanghai Key Laboratory of Magnetic Resonance, Department of Physics, East China Normal University
Email: jqli@phy.ecnu.edu.cn
ҚХР, 3663 North Zhongshan Road, Shanghai, 200062
Meining Chen
Shanghai Key Laboratory of Magnetic Resonance, Department of Physics, East China Normal University
Email: jqli@phy.ecnu.edu.cn
ҚХР, 3663 North Zhongshan Road, Shanghai, 200062
Mengchao Pei
Shanghai Key Laboratory of Magnetic Resonance, Department of Physics, East China Normal University
Email: jqli@phy.ecnu.edu.cn
ҚХР, 3663 North Zhongshan Road, Shanghai, 200062
Yi Wang
Shanghai Key Laboratory of Magnetic Resonance, Department of Physics, East China Normal University; Department of Radiology, Weill Medical College of Cornell University
Email: jqli@phy.ecnu.edu.cn
ҚХР, 3663 North Zhongshan Road, Shanghai, 200062; 515 East 71st St., Suite S106, New York, NY, 10021
Dongya Huang
Department of Neurology, School of Medicine, East Hospital Affiliated to Tongji University
Хат алмасуға жауапты Автор.
Email: dongyahuang77@hotmail.com
ҚХР, 150 Jimo Road, Pudong, Shanghai, 200120
Jianqi Li
Shanghai Key Laboratory of Magnetic Resonance, Department of Physics, East China Normal University
Хат алмасуға жауапты Автор.
Email: jqli@phy.ecnu.edu.cn
ҚХР, 3663 North Zhongshan Road, Shanghai, 200062
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