电邮这篇文章 Quantitative Susceptibility Mapping of the Substantia Nigra in Parkinson’s Disease
- 作者: Zhao X.1, An H.2, Liu T.3, Shen N.2, Bo B.1, Zhang Z.1, Weng P.1, Chen M.1, Pei M.1, Wang Y.1,3, Huang D.2, Li J.1
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隶属关系:
- Shanghai Key Laboratory of Magnetic Resonance, Department of Physics, East China Normal University
- Department of Neurology, School of Medicine, East Hospital Affiliated to Tongji University
- Department of Radiology, Weill Medical College of Cornell University
- 期: 卷 48, 编号 6 (2017)
- 页面: 533-544
- 栏目: Original Paper
- URL: https://journals.rcsi.science/0937-9347/article/view/247697
- DOI: https://doi.org/10.1007/s00723-017-0877-x
- ID: 247697
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详细
The purpose of this study was to evaluate the sensitivities of quantitative susceptibility mapping (QSM) and R2* mapping in clinical diagnoses of Parkinson’s disease (PD). QSM images and R2* maps from 29 patients with PD and 25 healthy controls were obtained on a clinical 3T magnetic resonance imaging (MRI) system using a three-dimensional multi-echo gradient-echo sequence. Two-tailed t tests and receiver operating characteristic curves analyses were applied to the mean values of QSM and R2* of the two groups. In the PD group, a two-tailed Pearson correlation analysis was used to investigate the correlations between MRI measures (susceptibility and R2* values) and the Unified Parkinson’s Disease Rating Scale-III (UPDRS-III) score. In the substantia nigra (SN), a significant difference between patients with PD and healthy controls was found on QSM (154.80 ± 43.36 vs. 127.50 ± 21.05 ppb, P = 0.006) but not on R2* mapping. The receiver operating characteristic curves showed that QSM was more sensitive than R2* mapping to distinguish PD patients from healthy controls, with areas under the curve equal to 0.68 and 0.51, respectively. The UPDRS-III motor scores did not correlate with mean susceptibility or R2* values in the PD group. In conclusion, QSM is a more accurate and sensitive method than R2* mapping to detect the pathologic changes in the SN of patients with PD.
作者简介
Xinxin Zhao
Shanghai Key Laboratory of Magnetic Resonance, Department of Physics, East China Normal University
Email: jqli@phy.ecnu.edu.cn
中国, 3663 North Zhongshan Road, Shanghai, 200062
Hedi An
Department of Neurology, School of Medicine, East Hospital Affiliated to Tongji University
Email: jqli@phy.ecnu.edu.cn
中国, 150 Jimo Road, Pudong, Shanghai, 200120
Tian Liu
Department of Radiology, Weill Medical College of Cornell University
Email: jqli@phy.ecnu.edu.cn
美国, 515 East 71st St., Suite S106, New York, NY, 10021
Nan Shen
Department of Neurology, School of Medicine, East Hospital Affiliated to Tongji University
Email: jqli@phy.ecnu.edu.cn
中国, 150 Jimo Road, Pudong, Shanghai, 200120
Binshi Bo
Shanghai Key Laboratory of Magnetic Resonance, Department of Physics, East China Normal University
Email: jqli@phy.ecnu.edu.cn
中国, 3663 North Zhongshan Road, Shanghai, 200062
Zhuwei Zhang
Shanghai Key Laboratory of Magnetic Resonance, Department of Physics, East China Normal University
Email: jqli@phy.ecnu.edu.cn
中国, 3663 North Zhongshan Road, Shanghai, 200062
Pengfei Weng
Shanghai Key Laboratory of Magnetic Resonance, Department of Physics, East China Normal University
Email: jqli@phy.ecnu.edu.cn
中国, 3663 North Zhongshan Road, Shanghai, 200062
Meining Chen
Shanghai Key Laboratory of Magnetic Resonance, Department of Physics, East China Normal University
Email: jqli@phy.ecnu.edu.cn
中国, 3663 North Zhongshan Road, Shanghai, 200062
Mengchao Pei
Shanghai Key Laboratory of Magnetic Resonance, Department of Physics, East China Normal University
Email: jqli@phy.ecnu.edu.cn
中国, 3663 North Zhongshan Road, Shanghai, 200062
Yi Wang
Shanghai Key Laboratory of Magnetic Resonance, Department of Physics, East China Normal University; Department of Radiology, Weill Medical College of Cornell University
Email: jqli@phy.ecnu.edu.cn
中国, 3663 North Zhongshan Road, Shanghai, 200062; 515 East 71st St., Suite S106, New York, NY, 10021
Dongya Huang
Department of Neurology, School of Medicine, East Hospital Affiliated to Tongji University
编辑信件的主要联系方式.
Email: dongyahuang77@hotmail.com
中国, 150 Jimo Road, Pudong, Shanghai, 200120
Jianqi Li
Shanghai Key Laboratory of Magnetic Resonance, Department of Physics, East China Normal University
编辑信件的主要联系方式.
Email: jqli@phy.ecnu.edu.cn
中国, 3663 North Zhongshan Road, Shanghai, 200062
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