Multinuclear Applications on 0.5 T Magnetic Resonance Scanner

Resumo

The article describes experiments on the detection of nuclear magnetic resonance (NMR) signals from nuclei other than protons on low field (0.5 T) clinical MR scanner. The possibility of obtaining NMR spectra and MR imaging (MRI) from nuclei with a high natural abundance (¹⁹F, ³¹P, ¹¹B, ²³Na), as well as isotope-enriched samples (¹³C and ²H), is presented. The possibilities of recording NMR spectra for low-sensitivity nuclei (¹³C, ²⁹Si, ²H, ¹⁷O, ¹⁴N) are shown. Special attention is paid to the detection of NMR signal from perfluorocarbons (PFC). The examples of ¹⁹F MRI of PFC obtained in the in vivo study of both animals and human are presented. The ¹⁹F MRI of fluorinated gas, which can be used as a contrast agent for lung imaging, was also obtained. The opportunity of increasing ¹³C NMR signal from PFC by polarization transfer from fluorine nuclei is demonstrated. It was shown that ²³Na can be detected in NMR spectroscopy and MRI of animal and human. The prospects of ¹⁷O NMR for technology applications are noticed.