电邮这篇文章 Identification of Markers for Dengue Infection in Patients after Visiting Dengue-Endemic Countries
- 作者: Ternovoi V.A.1, Plyasunova I.V.1, Sementsova A.O.1, Kartashov M.Y.1, Shvalov A.N.1, Chausov E.V.1, Eremeeva L.I.1, Protopopova E.V.1, Chub E.V.1, Bayandin R.B.1, Pyankov O.V.1, Loktev V.B.1, Agafonov A.P.1, Maksyutov R.A.1
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隶属关系:
- State Research Center of Virology and Biotechnology VECTOR
- 期: 卷 34, 编号 3 (2019)
- 页面: 188-194
- 栏目: Experimental Works
- URL: https://journals.rcsi.science/0891-4168/article/view/178382
- DOI: https://doi.org/10.3103/S0891416819030066
- ID: 178382
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详细
In studied blood serum samples from Russian patients hospitalized with suspected dengue fever, one or more markers of dengue fever have been detected, namely, viral RNA, NS1 antigen, and IgM or IgG antibodies. Moreover, only the combined use of various immunological and genetic methods provided a more effective diagnosis of dengue fever. The detection of IgG to dengue virus in patients with high titers of IgG to tick-borne encephalitis virus (TBEV) and, conversely, the detection of IgG to TBEV virus in patients with high titers of IgG to dengue has been documented. The results confirm the literature data on pronounced antigenic cross-sections between different representatives of flaviviruses, which may complicate the ELISA diagnosis of TBEV and dengue in patients. Genotyping of obtained dengue virus isolates showed that imported cases of dengue fever are caused by subtypes 1–4 of the dengue virus, with the prevalence of infection cases caused by dengue virus 1. Sequencing of these dengue virus isolates, including genome-wide, showed that viral isolates obtained on the territory of Russia are phylogenetically close to modern variants of the dengue virus circulating in the countries of Southeast Asia.
作者简介
V. Ternovoi
State Research Center of Virology and Biotechnology VECTOR
编辑信件的主要联系方式.
Email: tern@vector.nsc.ru
俄罗斯联邦, Novosibirsk oblast, 630559
I. Plyasunova
State Research Center of Virology and Biotechnology VECTOR
Email: tern@vector.nsc.ru
俄罗斯联邦, Novosibirsk oblast, 630559
A. Sementsova
State Research Center of Virology and Biotechnology VECTOR
Email: tern@vector.nsc.ru
俄罗斯联邦, Novosibirsk oblast, 630559
M. Kartashov
State Research Center of Virology and Biotechnology VECTOR
Email: tern@vector.nsc.ru
俄罗斯联邦, Novosibirsk oblast, 630559
A. Shvalov
State Research Center of Virology and Biotechnology VECTOR
Email: tern@vector.nsc.ru
俄罗斯联邦, Novosibirsk oblast, 630559
E. Chausov
State Research Center of Virology and Biotechnology VECTOR
Email: tern@vector.nsc.ru
俄罗斯联邦, Novosibirsk oblast, 630559
L. Eremeeva
State Research Center of Virology and Biotechnology VECTOR
Email: tern@vector.nsc.ru
俄罗斯联邦, Novosibirsk oblast, 630559
E. Protopopova
State Research Center of Virology and Biotechnology VECTOR
Email: tern@vector.nsc.ru
俄罗斯联邦, Novosibirsk oblast, 630559
E. Chub
State Research Center of Virology and Biotechnology VECTOR
Email: tern@vector.nsc.ru
俄罗斯联邦, Novosibirsk oblast, 630559
R. Bayandin
State Research Center of Virology and Biotechnology VECTOR
Email: tern@vector.nsc.ru
俄罗斯联邦, Novosibirsk oblast, 630559
O. Pyankov
State Research Center of Virology and Biotechnology VECTOR
Email: tern@vector.nsc.ru
俄罗斯联邦, Novosibirsk oblast, 630559
V. Loktev
State Research Center of Virology and Biotechnology VECTOR
Email: tern@vector.nsc.ru
俄罗斯联邦, Novosibirsk oblast, 630559
A. Agafonov
State Research Center of Virology and Biotechnology VECTOR
Email: tern@vector.nsc.ru
俄罗斯联邦, Novosibirsk oblast, 630559
R. Maksyutov
State Research Center of Virology and Biotechnology VECTOR
Email: tern@vector.nsc.ru
俄罗斯联邦, Novosibirsk oblast, 630559
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