Association Study of Nuclear Abnormalities and Polymorphisms of Oxidative Stress Genes with Endemic Goiter Incidence
- 作者: Bisultanova Z.1, Dzhambetova L.1, Machigov E.1, Atsaeva M.1, Dzhambetova P.1
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隶属关系:
- Department of Nuclear Biology, Morphology and Microbiology, Chechen State University
- 期: 卷 34, 编号 4 (2019)
- 页面: 237-243
- 栏目: Article
- URL: https://journals.rcsi.science/0891-4168/article/view/178403
- DOI: https://doi.org/10.3103/S0891416819040025
- ID: 178403
如何引用文章
详细
Endemic goiter is one of the most common endocrine diseases in Russian Federation. There is a strong need for new methods to detect and treat this disease. Analysis of nuclear abnormalities in buccal epithelial cells can be used to estimate overall exposure of patients to various endo- and exogenic factors associated with a disorder. We performed an association study of nuclear abnormalities in buccal epithelial cells and as well polymorphisms of genes encoding superoxide dismutase 1 (SOD1) and superoxide dismutase 2 (SOD2) in patients with endemic goiter. We observed an increased frequency of nuclear abnormalities related to early stages of apoptosis and necrosis in buccal epithelial cells of patients with endemic goiter when compared to cells from healthy individuals. Nuclear abnormalities in patients with endemic goiter are more common in heterozygous carriers of minor alleles of SOD1 G7958A and SOD2 58T>C polymorphisms when compared to homozygous individuals. Furthermore the presence of minor allele of SOD2 60C>T polymorphism in individuals with endemic goiter decreases the frequency of nuclear abnormalities. The results of this study could be used for the further development of effective and low-cost methods of endemic goiter diagnostics.
作者简介
Z. Bisultanova
Department of Nuclear Biology, Morphology and Microbiology, Chechen State University
Email: dzhambetova_chsu@bk.ru
俄罗斯联邦, Grozny, 364024
L. Dzhambetova
Department of Nuclear Biology, Morphology and Microbiology, Chechen State University
Email: dzhambetova_chsu@bk.ru
俄罗斯联邦, Grozny, 364024
E. Machigov
Department of Nuclear Biology, Morphology and Microbiology, Chechen State University
Email: dzhambetova_chsu@bk.ru
俄罗斯联邦, Grozny, 364024
M. Atsaeva
Department of Nuclear Biology, Morphology and Microbiology, Chechen State University
Email: dzhambetova_chsu@bk.ru
俄罗斯联邦, Grozny, 364024
P. Dzhambetova
Department of Nuclear Biology, Morphology and Microbiology, Chechen State University
编辑信件的主要联系方式.
Email: dzhambetova_chsu@bk.ru
俄罗斯联邦, Grozny, 364024