Use of Demineralized Bone Matrix to Repair Damaged Long Bones with Significant Defects

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Abstract

Introduction of tubular perforated implants of demineralized bone matrix was shown to provide the formation of organ specific bone regenerate and restoration of full value anatomic structure of the injured bone. Shape, material, method of matrix implantation conditioned the development of longitudinally oriented compact bone between free cortical distal and proximal bone fragments as well as the restoration of bone marrow intergrity in the defect site and its intergra-tion with bone marrow of total bone. Implant structure having multilevel widely branched canal system is suggested to provide free microcirculation of tissue liquid and migration of bone cell precursors into osteogenesis area.

 

About the authors

N. P. Omelianenko

Central Institute of Traumatology and Orthopedics. N.N. Priorov

Author for correspondence.
Email: info@eco-vector.com
Russian Federation

N. N. Karpov

Central Institute of Traumatology and Orthopedics. N.N. Priorov

Email: info@eco-vector.com
Russian Federation

I. V. Matveychuk

Research Center for Biological Structures NPO VILAR

Email: info@eco-vector.com
Russian Federation, Moscow

A. I. Dorokhin

Central Institute of Traumatology and Orthopedics. N.N. Priorov

Email: info@eco-vector.com
Russian Federation

References

Supplementary files

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1. JATS XML
2. Rice. Fig. 1. Scheme of a model of a tubular perforated implant (a) and its installation (b). The implant was placed in a rabbit radius defect (c).

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3. Rice. 2. Fragment of the forearm of a rabbit, 1st day after the operation.

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4. Rice. Fig. 3. Fragment of a rabbit forearm, 2 months after surgery. a — histological section (Van Gieson stain, magnification 10): newly formed bone (I) at the site of the bone defect, local consolidation of the radius and ulna (II), implant remnant ( III), intraosseous bridge (IV); b — radiograph.

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5. Rice. Fig. 4. Fragment of the forearm of a rabbit, 4 months after surgery. a — histological section (Van Gieson stain, magnification 10): the radius was completely restored. Cortical part (I) and bone marrow (II), thickening of the cortical part (III); b — radiograph.

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