Use of Demineralized Bone Matrix to Repair Damaged Long Bones with Significant Defects

Introduction of tubular perforated implants of demineralized bone matrix was shown to provide the formation of organ specific bone regenerate and restoration of full value anatomic structure of the injured bone. Shape, material, method of matrix implantation conditioned the development of longitudinally oriented compact bone between free cortical distal and proximal bone fragments as well as the restoration of bone marrow intergrity in the defect site and its intergra-tion with bone marrow of total bone. Implant structure having multilevel widely branched canal system is suggested to provide free microcirculation of tissue liquid and migration of bone cell precursors into osteogenesis area.