The use of plastic material "perfoost" in the clinic of pediatric bone pathology

Cover Page

Cite item

Full Text

Abstract

Osseous-plastic material «Perfoost» — demineralized lyophilized perforated allografs- was elaborated at CITO in 1997. Study of mechanical characteristics showed that «Perfoost» grafts had high plasticity. Mechanical stiffness allowed to use that material for substitution of marginal bone defects. Study in vitro showed high efficacy of cloning that was indirect evidence that demineralized allografts had osteoinductive properties. Between 1998—2002 at the Department of bone pathology for children and adolescents 121 patients, aged 1—18, with primary tumor, tumor-like diseases and systemic inherited skeleton pathology were operated on with «Perfoost». Follow up period ranged from 1 years to 4 years 10 months. In vast bone defects demineralized allografts were used in combination with frozen cortical implants and metallosteosynthesis. Restoration of bone tissue was achieved in the period from 8 to 12 months. In patients with fibrous dysplasia who underwent extensive bone resection, the time of bone restoration increased by 16 months. Good and satisfactory results were observed in 98,3% of patients.

About the authors

A. I. Snetkov

Central Research Institute of Traumatology and Orthopedics. N.N. Priorova

Email: info@eco-vector.com
Russian Federation, Moscow

M. V. Lekishvili

Central Research Institute of Traumatology and Orthopedics. N.N. Priorova

Email: info@eco-vector.com
Russian Federation, Moscow

M. A. Kasymov

Central Research Institute of Traumatology and Orthopedics. N.N. Priorova

Email: info@eco-vector.com
Russian Federation, Moscow

V. K. Ilina

Central Research Institute of Traumatology and Orthopedics. N.N. Priorova

Email: info@eco-vector.com
Russian Federation, Moscow

S. Y. Batrakov

Central Research Institute of Traumatology and Orthopedics. N.N. Priorova

Email: info@eco-vector.com
Russian Federation, Moscow

M. G. Vasiliev

Central Research Institute of Traumatology and Orthopedics. N.N. Priorova

Email: info@eco-vector.com
Russian Federation, Moscow

A. M. Avakyan

Central Research Institute of Traumatology and Orthopedics. N.N. Priorova

Email: info@eco-vector.com
Russian Federation, Moscow

R. P. Pavlov

Central Research Institute of Traumatology and Orthopedics. N.N. Priorova

Email: info@eco-vector.com
Russian Federation, Moscow

A. A. Fazilova

Central Research Institute of Traumatology and Orthopedics. N.N. Priorova

Author for correspondence.
Email: info@eco-vector.com
Russian Federation, Moscow

References

  1. Виноградова Т.П., Лаврищева Г.И. Регенерация и пересадка костей. — М.,1974.
  2. Касымов И.А., Гаврюшенко Н.С. //Вестн. травматол. ортопед. — 1999. — N 2. — С. 62-65.
  3. Касымов И.А. Костно-пластические оперативные вмешательства у детей с костной патологией: Автореф. дис.... д-ра мед. наук. — М.,2000.
  4. Савельев В.И. //Получение и клиническое применение деминерализованных костных трансплантатов: Сб. науч. трудов. — Л.,1987. — С. 4—13.
  5. Слуцкий Л.И., Севастьянова Н.А. //Ортопед. травматол. — 1986. — N 8. — С. 69-73.
  6. Хэм А., Кормак Д. Гистология. — М.,1983. — Т. 3. — С. 126-131.
  7. Geesink R.G.T., Hoefnagels N.H.M., Bulstra S.K. //J. Bone Jt Surg. — 1999. — Vol. 81B, N 4. — P. 710-718.
  8. Gendler E. //J. Biomed. Mat. Res. — 1986. — Vol. 20, N 6. — P. 687-697.
  9. Lekishvili M.V., Il’ina V.K., Vasiliev M.G. // Third World Congress on Tissue Banking and 26th Annual Meeting AATB. — Boston,2002. — P. 113.
  10. Reddi A.H., Huggins C. //Proc. Natl. Acad. Sci. USA. — 1972. — Vol. 69. — P. 1601-1605.
  11. Reddi A.H. //Clin. Orthop. — 1998. — N 355. — P. S66-72.
  12. Younger E.M., Chapman M.W //J. Orthop. Trauma. — 1989. — Vol. 3, N 3. — P. 192-195.
  13. Urist M.R., Dowell T.A., Hay P.H., Strates B.S. //Clin. Orthop. — 1968. — N 59. — P. 59—96.

Supplementary files

Supplementary Files
Action
1. JATS XML
Download
2. Fig. 1. Radiographs of patient R., 12 years old. Diagnosis: non-ossifying fibroma of the upper third of the left humerus. a - before surgery; b — after marginal resection of the upper third of the humerus and alloplasty with “Perfoost”; c — 12 months after the operation.

Download (278KB)
Indexing metadata
3. Fig. 2. Radiographs of patient S., 15 years old. Diagnosis: chondroblastoma of the distal epiphysis of the left femur. a - before surgery; b — after subchondral resection of the distal epiphysis of the femur and alloplasty "Perfoost" ("bone gravel").

Download (257KB)
Indexing metadata
4. Fig. 3. Radiographs of the patient M., 16 years old. Diagnosis: fibrous dysplasia of the right femur. a - before surgery; b — after extensive marginal resection and alloplasty with Perfoost in combination with frozen cortical implants with fixation with an L-shaped plate; c — after 12 months; d — 3 years after the operation.

Download (812KB)
Indexing metadata
5. Fig. 4. Radiographs of the patient Ch. 11 years old. Deformities of the lower extremities on the basis of imperfect osteogenesis. a - before surgery; b — after periosteal alloplasty with Perfoost in combination with intramedullary osteosynthesis; c — 6 months after the operation.

Download (457KB)
Indexing metadata
6. Fig. 5. Radiographs of patient F., 15 years old. Shortening of the right humerus due to a solitary cyst. a - before surgery; b — after marginal resection of the upper third of the humerus, alloplasty with Perfoost, and lengthening on the implant in the Ilizarov apparatus for 14 days.

Download (237KB)
Indexing metadata
7. Fig. 6. Radiographs of patient S., 16 years old. Diagnosis: vitamin D-resistant rickets. a — weak mineralization of the regenerate of the right tibia in the Ilizarov apparatus; b — after alloplasty using Perfoostom regenerate with a high degree of demineralization; c — 5 months after alloplasty.

Download (800KB)
Indexing metadata

Copyright (c) 2003 Eco-Vector



This website uses cookies

You consent to our cookies if you continue to use our website.

About Cookies