Email this article Metabolic Correction of Cerebral Radiation Syndrome in Small and Large Animals
- Authors: Vasin M.V.1, Ilyin L.A.1, Chernov Y.N.2, Ushakov I.B.1
-
Affiliations:
- Burnazyan Federal Medical Biophysical Center of FMBA of Russia
- Burdenko Voronezh State Medical University
- Issue: Vol 63, No 3 (2023)
- Pages: 255-260
- Section: МОДИФИКАЦИЯ РАДИАЦИОННЫХ ЭФФЕКТОВ
- URL: https://journals.rcsi.science/0869-8031/article/view/137684
- DOI: https://doi.org/10.31857/S0869803123020133
- EDN: https://elibrary.ru/FGTYBV
- ID: 137684
Cite item
Open Access
Access granted
Subscription Access
Abstract
In experiments on mice, rats, guinea pigs and dogs, the effectiveness of metabolic correction of cerebral radiation syndrome with nicotinic and succinic acids and Esseentiale was evaluated. The animals were totally exposed to 5–8 and 16–20 MeV pulsed electron flux at doses of 85–110 or 500–570 Gy or to gamma irradiation at a dose of 100 Gy. The frequency and time of ataxia and convulsions, as well as the dynamics of animal death after radiation were recorded. Nicotinic and succinic acids (500 mg/kg each) and Esseenciale (20 mg/kg by nicotinamide) reduced the frequency and delayed the onset of ataxia and seizures equally in both small laboratory animals and dogs. In experiments on rats after exposure at a dose of 100 Gy under the influence of radiation and Essentiale, there was no significant change in animal cognitive function according to the decision-making test at the first presentation of a new deposit.
About the authors
M. V. Vasin
Burnazyan Federal Medical Biophysical Center of FMBA of Russia
Email: iushakov@fmbcfmba.ru
Russia, Moscow
L. A. Ilyin
Burnazyan Federal Medical Biophysical Center of FMBA of Russia
Email: iushakov@fmbcfmba.ru
Russia, Moscow
Yu. N. Chernov
Burdenko Voronezh State Medical University
Email: iushakov@fmbcfmba.ru
Russia, Voronezh
I. B. Ushakov
Burnazyan Federal Medical Biophysical Center of FMBA of Russia
Author for correspondence.
Email: iushakov@fmbcfmba.ru
Russia, Moscow
References
- Лышов В.Ф., Васин М.В., Чернов Ю.Н. Изменение активности окислительных и гидролитических ферментов коры головного мозга животных в ранние сроки после облучения в условиях применения мексамина и синтетического аналога простагландина F2-эстрофана // Радиобиология. 1988. Т. 28. № 4. С. 539–542. [Lyshov V.F., Vasin M.V., Chernov Yu.N. Changes in the activity of the oxidative and hydrolytic enzymes of the animal cerebral cortex in the early periods after gamma irradiation and the use of meksamine and the synthetic analog of prostaglandin F2 alpha-estrofan // Radiobiologiya. 1988. V. 28. № 4. P. 539–542. (In Russ.)]
- Лышов В.Ф., Васин М.В., Чернов Ю.Н. О влиянии воздействия ускоренных электронов и γ-квантов 60Со на активность окислительных и гидролитических ферментов головного мозга крыс // Радиобиология. 1992. Т. 32. № 1. С. 56–59. [Lyshov V.F., Vasin M.V., Chernov Yu.N. The effect of exposure to 60Co accelerated electrons and gamma quanta on the activity of oxidative and hydrolytic enzymes in the rat brain // Radiobiologiya. 1992. V. 32. № 1. P. 56–59. (In Russ.)]
- Popov D., Maliev S. Cerebrovascular acute radiation syndrome: radiation neurotoxins, mechanisms of toxi-city, neuroimmune interactions // 38th COSPAR Scientific Assembly. 18–15 July 2010. Bremen, 2010. P. 3.
- Малаховский В.Н. Острые радиационные церебральные нарушения как эффект церебрального ДНК повреждения // Радиобиология. 1993. Т. 33. № 3. С. 392–397. [Malahovsky V.N. Acute radiation cerebral disorders as an effect of cerebral DNA da-mage // Radiobiologiya. 1993. V. 33. № 3. P. 392–397. (In Russ.)]
- Nosov A.V., Ivnitsky Yu.Yu., Malakhovsky V.N. Metabolic correction of cerebral radiation syndrome // Radiat. Res.1999. V. 152. № 5. P. 523–529.
- Ивницкий Ю.Ю., Носов А.В., Малаховский В.Н. Механизм церебрального радиационного синдрома // Радиац. биология. Радиоэкология 2001. Т. 41. № 1. С. 44–55. [Ivnicky Yu.Yu., Nosov A.V., Malahovsky V.N. Mechanisms of cerebral radiation syndrome // Radiat. biol. Radioecol. 2001. V. 41. № 1. P. 44–55. (In Russ.)]
- Справочник Видаля. Лекарственные препараты в России. М.: “АстраФармСервис”, 1998. С. Б794. [Vidal. Drugs in Russia. Moscow: AstraPharmSrvice, 1998. P. B794 (In Russ.)]]
- Чернов Ю.Н., Васин М.В., Комарова С.Н. Экспериментальная модель эвристических решений в опытах на крысах для фармакологического скрининга // Фармакол. токсикол. 1989. Т. 52. № 4. С. 96–99. [Chernov Yu.N., Vasin M.V., Komarova S.N. Experimental model of heuristic decision making in experiments on rats for pharmacologic screening // Pharmacol. Toxicol. 1989. V. 52. № 4. P. 96–99. (In Russ.)]
- Turetz M.L., Crystal R.G. Mechanisms and consequences of central nervous system hypoxia // Neurobiology of disease / Ed. S. Gilman. N.Y.: Academic Press, 2007. P. 681. https://doi.org/10.1016/B978-012088592-3/50064-5
- Kempermann G., Song G.H., Gage F.H. Neurogenesis in the adult hippocampus // Cold Spring Harb. Perspect. Biol. 2015. V. 7. № 9: a018812. https://doi.org/10.1101/cshperspect.a018812
- Чернов Ю.Н., Васин М.В., Ушаков И.Б. Влияние эссенциале Н на выживаемость крыс при воздействии продольных перегрузок “голова–таз” (+Gz) и острой гипоксической гипоксии // Эксперим. клин. фармакол. 2021. Т. 84. № 3. С. 8–10. [Chernov Yu.N., Vasin M.V., Ushakov I.B. Effects of essentiale H on rat survival under exposure to longitudinal head-pelvic overloads (+Gz) and acute hypoxic hypoxia // Exp. Clin. Pharmacol. 2021. V. 84. № 3. P. 8–10. (In Russ.)]https://doi.org/10.30906/0869-2092-2021-84-3-8-10
- Васин М.В., Рясина Т.В., Чернов Ю.Н. Антиоксидантные свойства и антиоксидантный эффект “эссенциале” // Цитология. 1999. Т. 41. № 9. С. 812–813. [Vasin M.V., Ryasina T.V., Chernov Yu.N. Antioksidantnye svojstva i antioksidantnyj effekt “essenciale” // Cytologiya. 1999. V. 41. № 9. P. 812–813. (In Russ.)]
- Yang J., Klaidman L.K. Chang M.L. et al. Nicotinamide therapy protects against both necrosis and apoptosis in a stroke model // Pharmacol. Biochem. Behav. 2002. V. 73. № 4. P. 901. https://doi.org/10.1016/s0091-3057(02)00939-5
- Hoane M.R., Akstulewicz S.L., Toppen J.J. Treatment with vitamin B3 improves functional recovery and reduces GFAP expression following traumatic brain injury in rats // Neurotrauma. 2003. V. 20. № 11. P. 1189–1199. https://doi.org/10.1089/089771503770802871
- Klimova N., Fearnow A., Long A., Kristian T. NAD+ precursor modulates post-ischemic mitochondrial fragmentation and reactive oxygen species generation via SIRT3 dependent mechanisms // Exp. Neurol. 2020. V. 325. № 113144. https://doi.org/10.1016/j.expneurol.2019.113144
- Васин М.В., Ильин Л.А., Ушаков И.Б. Анализ действия экзогенного никотинамида на биоэнергетические процессы в головном мозге при острой гипоксии // Биофизика. 2022. Т. 67. № 4. С. 792–797. [Vasin M.V., Ilyin L.A., Ushakov I.B. Analysis of the Effect of Exogenous Nicotinamide on Bioenergetic Processes in the Brain During Acute Hypoxia // Biophysics. 2022. V. 67. V. 4. P. 637–641. https://doi.org/10.1134/S0006350922040224 (In Russ.)]
