Chemerin as a cardiovascular biological marker: Present and future
- 作者: Alieva A.1, Reznik E.1, Teplova N.1, Baykova I.1, Shnakhova L.2, Kotikova I.1, Shekshebekova A.1, Nikitin I.1
-
隶属关系:
- Pirogov Russian National Research Medical University
- I.M. Sechenov First Moscow State Medical University (Sechenov University)
- 期: 卷 29, 编号 3 (2023)
- 页面: 199-216
- 栏目: Reviews
- URL: https://journals.rcsi.science/0869-2106/article/view/131854
- DOI: https://doi.org/10.17816/medjrf255397
- ID: 131854
如何引用文章
详细
Cardiovascular diseases are the leading cause of invalidity and mortality in the majority of developed countries and are recognized by the international community as a pandemic problem. An important task of modern cardiology is the search and study of new biological markers.
This literature review aimed to consider chemerin as a new diagnostic and prognostic marker for cardiovascular pathologies. Thus far, studies on chemerin indicate the possibility of its use as a marker of cardiovascular pathology. Evidence points to the important role of chemerin in the development and progression of cardiovascular diseases. As an adipokine, chemerin modulates glucose, and lipid levels, thereby influencing lipid deposition in the endothelium and progression of atherosclerosis. As a chemoattractant, it facilitates the mobilization and interaction of macrophages with dendritic cells and natural killer cells in the vascular system and induces endothelial angiogenesis. The established role of chemerin in vascular inflammation, angiogenesis, and blood pressure modulation opens serious prospects for the development of therapeutics targeting this biomarker for the treatment of cardiovascular diseases. Several candidates targeting chemerin and the CMRK1 signaling pathway have shown promising potential in reducing vascular dysfunction in in vitro and in vivo studies. Further studies analyzing the efficacy and safety of new chemerin-targeting drugs are needed to assess their potential.
作者简介
Amina Alieva
Pirogov Russian National Research Medical University
编辑信件的主要联系方式.
Email: amisha_alieva@mail.ru
ORCID iD: 0000-0001-5416-8579
SPIN 代码: 2749-6427
MD, Cand. Sci. (Med.), associate professor
俄罗斯联邦, 1 Ostrovityanova street, 117997 MoscowElena Reznik
Pirogov Russian National Research Medical University
Email: elenaresnik@gmail.com
ORCID iD: 0000-0001-7479-418X
SPIN 代码: 3494-9080
Researcher ID: N-6856-2016
MD, Dr. Sci. (Med.), professor
俄罗斯联邦, 1 Ostrovityanova street, 117997 MoscowNatalia Teplova
Pirogov Russian National Research Medical University
Email: teplova.nv@yandex.ru
ORCID iD: 0000-0002-7181-4680
SPIN 代码: 9056-1948
MD, Dr. Sci. (Med.), professor
俄罗斯联邦, 1 Ostrovityanova street, 117997 MoscowIrina Baykova
Pirogov Russian National Research Medical University
Email: 1498553@mail.ru
ORCID iD: 0000-0003-0886-6290
SPIN 代码: 3054-8884
MD, Cand. Sci. (Med.), associate professor
俄罗斯联邦, 1 Ostrovityanova street, 117997 MoscowLidiya Shnakhova
I.M. Sechenov First Moscow State Medical University (Sechenov University)
Email: shnakhova_l_m@staff.sechenov.ru
ORCID iD: 0000-0003-3000-0987
SPIN 代码: 5549-5823
MD
俄罗斯联邦, MoscowIrina Kotikova
Pirogov Russian National Research Medical University
Email: kotikova.ia@mail.ru
ORCID iD: 0000-0001-5352-8499
SPIN 代码: 1423-7300
student
俄罗斯联邦, 1 Ostrovityanova street, 117997 MoscowAlpiyat Shekshebekova
Pirogov Russian National Research Medical University
Email: shekhshebekovaa@mail.ru
ORCID iD: 0000-0002-8600-9115
resident
俄罗斯联邦, 1 Ostrovityanova street, 117997 MoscowIgor Nikitin
Pirogov Russian National Research Medical University
Email: igor.nikitin.64@mail.ru
ORCID iD: 0000-0003-1699-0881
SPIN 代码: 3595-1990
MD, Dr. Sci. (Med.), professor
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