The causes of development of pulmonary hypertension under obesity


Cite item

Full Text

Abstract

The article presents the results of study demonstrating that though evident symptoms of pulmonary hypertension were absent (maximal systolic tension was within standards both in males and females of main group) reliable increasing of blood pressure in pulmonary artery in comparison with control group under increasing of body mass index, waist volume and index waist/hips. At that, in males of main group under obesity degree I and II average blood pressure exceeded limits of standards.

About the authors

Veronika S. Pshennova

The N.I. Pirogov Russian national research medical university Minzdrav of Russia

Email: terapia-mbf@mail.ru
MD, PhD, assistant of the department of Internal Medicine Medicobiologic faculty 117997, Moscow, Russia

O. V Aleksandrov

The N.I. Pirogov Russian national research medical university Minzdrav of Russia

117997, Moscow, Russia

References

  1. Чумакова Г.А., Веселовская Н.Г., Козаренко А.А., Воробьева Ю.В. Особенности морфологии, структуры и функции сердца при ожирении. Российский кардиологический журнал. 2012; 4 (96): 93-9.
  2. Юнусов Р.А., Исамитдинова И.М. Состояние внешнего дыхания и центральной гемодинамики у больных с алиментарно-конституциональным ожирением. Казанский медицинский журнал. 1991; 69 (4): 25-9.
  3. Драпкина О.М., Попова И.Р. Роль ожирения в развитии артериальной гипертензии и неалкогольной жировой болезни печени. Consilium Medicum. 2012; 14 (12): 72-6.
  4. Оганов Р.Г., Масленникова Г.Я. Гендерные различия кардиоваскулярной патологии. Кардиоваскулярная терапия и профилактика. 2012; 11 (4): 101-4.
  5. Adams K.F., Schatzkin A., Harris T.B., Kipnis V., Mouw T., Ballard-Barbash R. et al. Overweight, obesity, and mortality in a large prospective cohort of persons 50 to 71 years old. N. Engl. J. Med. 2006; 355: 763-78.
  6. Berrington de Gonzalez A., Hartge P., Cerhan J.R., Flint A.J., Hannan L., MacInnis R.J. et al. Body-mass index and mortality among 1.46 million white adults. N. Engl. J. Med. 2010; 363: 2211-9.
  7. Ware L.B., Matthay M.A. The acute respiratory distress syndrome. Health and Nutrition Examination Survey. Mayo Clin. Proc. 2011; 86: 105-12.
  8. Haque A.K., Gadre S., Taylor J., Haque S.A., Freeman D., Duarte A. Pulmonary and cardiovascular complications of obesity: An autopsy study of 76 obese subjects. Arch. Pathol. Lab. Med. 2008; 132 (9): 1397-404.
  9. Burger C.D., Foreman A.J., Miller D.P., Saff ord R.E., McGoon M.D., Badesch D.B. Comparison of body habitus in patients with pulmonary arterial hypertension enrolled in the Registry to Evaluate Early and Long-term PAH Disease Management with normative values from the National. Mayo Clin. Proc. 2011; 86 (2): 105-12.
  10. Kimura K., Tsuda K., Bada A., Kawabe T., Boh-oka S., Ibata M. et al. Involvement of nitric oxide in endothelium-dependent arterial relaxation by leptin. Biochem. Biophysic. Res. Commun. 2000; 273 (2): 745-9.
  11. Raj M. Obesity and cardiovascular risk in children and adolescents. Indian. J. Endocrinol. Metab. 2012; 16(1): 13-9.
  12. Friedman S.E., Andrus B.W. Obesity and pulmonary hypertension: a review of pathophysiologic mechanisms. J. Obes. 2012; 2012: 505274.
  13. Xu H., Barnes G.T., Yang Q., Tan G., Yang D., Chou C.J. et al. Chronic inflammation in fat plays a crucial role in the development of obesity-related insulin resistance. J. Clin. Invest. 2003; 112: 1821-30.
  14. Summer R., Walsh K., Medoff B.D. Obesity and pulmonary arterial hypertension: Is adiponectin the molecular link between these conditions? Pulm. Circ. 2011; 1 (4): 440-7.
  15. Lopez-Lopez J.G., Moral-Sanz J., Frazziano G., Gomez-Villalobos M.J., Moreno L., Menendez C. et al. Type 1 diabetes-induced hyperresponsiveness to 5-hydroxytryptamine in rat pulmonary arteries via oxidative stress and induction of cyclooxygenase-2. J. Pharmacol. Exp. Ther. 2011; 338 (1): 400-7.
  16. Martin S.S., Qasim A., Reilly M.P. Leptin resistance. J. Am. Coll. Cardiol. 2008; 52 (15): 1201-10.
  17. Zharikov S.I., Swenson E.R., Lanaspa M., Block E.R., Patel J.M., Johnson R.J. Could uric acid be a modifiable risk factor in subjects with pulmonary hypertension? Med. Hypotheses. 2010; 74 (6): 1069-74.
  18. Sood A. Altered resting and exercise respiratory physiology in obesity. Clin. Chest. Med. 2009; 30(3): 445-54.
  19. Griffith J.S., Jensen S.M., Lunceford J.K., Kahn M.W., Zheng Y., Falase E.A. et al. Evidence for the genetic control of estradiol-regulated responses. Implications for variation in normal and pathological hormone-dependent phenotypes. Am. J. Pathol. 1997; 150(6): 2223-30.
  20. Hamano N., Terada N., Maesako K., Numata T., Konno A. Effect of sex hormones on eosinophilic inflammation in nasal mucosa. Allergy Asthma Proc. 1998; 19 (5): 263-9.

Supplementary files

Supplementary Files
Action
1. JATS XML
Download

Copyright (c) 2016 Eco-Vector


 


Согласие на обработку персональных данных

 

Используя сайт https://journals.rcsi.science, я (далее – «Пользователь» или «Субъект персональных данных») даю согласие на обработку персональных данных на этом сайте (текст Согласия) и на обработку персональных данных с помощью сервиса «Яндекс.Метрика» (текст Согласия).