THE DYNAMICS OF MATRIX PROTEINS EXCRETION WITH URINE UNDER PYELONEPHRITIS IN CHILDREN


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Abstract

In children, infectious inflammatory diseases of organs of urinary system, pyelonephritis included, can result in renal tissue hardening as a result of excessive accumulation of components of extracellular matrix in interstitial tissue due to imbalance in the synthesis/proteins degradation system of extracellular matrix. The degradation of proteins occurs under impact of proteinases, in particular matrix metalloproteinases named as biological markers of fibrosis. The study covered the evaluation of content of metalloproteinases 2 and 9 and tissue inhibitor of matrix metalloproteinases 1 in urine of 135 children with pyelonephritis. The established disorders of balance between pro-inflammatory and antiinflammatory, pro-sclerotic compounds can testify the atypical course of inflammation with subsequent formation of sclerosis focuses. This is needed for assigning the treatment tactics and following-up of patients with pyelonephritis.

About the authors

Yu. A Leontiyeva

The N.I. Pirogov Russian research medical university of Minzdrav of Russia

Email: leontieva.ju@yandex.ru
аспирант каф. детских болезней лечебного факультета

S. S Paunova

The N.I. Pirogov Russian research medical university of Minzdrav of Russia

Кафедра детских болезней лечебного факультета

A. G Kutcherenko

The Russian academy of medical sciences

I. E Smirnov

The Russian academy of medical sciences

L. A Revenkova

The N.I. Pirogov Russian research medical university of Minzdrav of Russia

Кафедра детских болезней лечебного факультета

E. A Temerina

The N.I. Pirogov Russian research medical university of Minzdrav of Russia

Кафедра детских болезней лечебного факультета

O. V Anokhina

The N.I. Pirogov Russian research medical university of Minzdrav of Russia

Кафедра детских болезней лечебного факультета

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